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Difference between revisions of "Chondro-osseous tumours"
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*Ctyologically benign cells is spaced nests. | *Ctyologically benign cells is spaced nests. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Enchondroma_-_intermed_mag.jpg | Enchondroma - intermed mag. (WC) | |||
Image:Enchondroma_-_very_high_mag.jpg | Enchondroma - very high mag. (WC) | |||
</gallery> | |||
==Chondroblastoma== | ==Chondroblastoma== | ||
===General=== | ===General=== | ||
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*Well-differentiated [[chondrosarcoma]]. | *Well-differentiated [[chondrosarcoma]]. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Chondroblastoma_-_intermed_mag.jpg | Chondroblastoma - intermed. mag. (WC) | |||
Image:Chondroblastoma_-_very_high_mag.jpg | Chondroblastoma - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | *[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-996.jpg Chondroblastoma (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | ||
*[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | *[http://img.medscape.com/pi/emed/ckb/orthopedic_surgery/1230552-1254949-997.jpg Chondroblastoma with "chickenwire" appearance (medscape.com)].<ref name=emed_chondroblastoma>URL: [http://emedicine.medscape.com/article/1254949-diagnosis http://emedicine.medscape.com/article/1254949-diagnosis]. Accessed on: 31 December 2010.</ref> | ||
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*[[Osteosarcoma]] - esp. [[chondroblastic osteosarcoma]] - has osteoid, may be focal. | *[[Osteosarcoma]] - esp. [[chondroblastic osteosarcoma]] - has osteoid, may be focal. | ||
Images | =====Images===== | ||
<gallery> | |||
Image:Chondrosarcoma_(1).jpg | Chondrosarcoma - low mag. (WC) | |||
Image:Chondrosarcoma_(2).jpg | Chondrosarcoma - high mag. (WC) | |||
Image:Chondrosarcoma_(3).jpg | Chondrosarcoma - high mag. (WC) | |||
</gallery> | |||
*www: | *www: | ||
**[http://path.upmc.edu/cases/case168.html Chondrosarcoma (upmc.edu)]. | **[http://path.upmc.edu/cases/case168.html Chondrosarcoma (upmc.edu)]. | ||
| Line 544: | Line 549: | ||
*Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]''.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | *Histomorphologically near identical/indistinguishable from ''[[osteoblastoma]]''.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | ||
Images: | ====Images==== | ||
<gallery> | |||
Image:Osteoid_osteoma_-_low_mag.jpg | Osteoid osteoma - low mag. (WC) | |||
Image:Osteoid_osteoma_-_high_mag.jpg | Osteoid osteoma - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://library.med.utah.edu/WebPath/COW/COW211.html Osteoid osteoma - CT scan (med.utah.edu)]. | *[http://library.med.utah.edu/WebPath/COW/COW211.html Osteoid osteoma - CT scan (med.utah.edu)]. | ||
*[http://www.sciencephoto.com/images/imagePopUpDetails.html?pop=1&id=700030210&pviewid=&country=67&search=gschmeissners&matchtype=FUZZY Osteoid osteoma (sciencephoto.com)]. | *[http://www.sciencephoto.com/images/imagePopUpDetails.html?pop=1&id=700030210&pviewid=&country=67&search=gschmeissners&matchtype=FUZZY Osteoid osteoma (sciencephoto.com)]. | ||
==Osteoblastoma== | ==Osteoblastoma== | ||
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*'''Must''' be greater 1.5 cm by definition.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | *'''Must''' be greater 1.5 cm by definition.<ref name=Ref_Sternberg4_286>{{Ref Sternberg4|286}}</ref> | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Osteoblastoma_-_high_mag.jpg | Osteoblastoma - high mag. (WC) | |||
Image:Osteoblastoma_-_low_mag.jpg | Osteoblastoma - low mag. (WC) | |||
</gallery> | |||
==Ewing sarcoma== | ==Ewing sarcoma== | ||
*[[AKA]] EWS/pPNET, AKA (confusingly) EWS/PNET: | *[[AKA]] EWS/pPNET, AKA (confusingly) EWS/PNET: | ||
| Line 613: | Line 622: | ||
*[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref> | *[[Rhabdomyosarcoma]] occasionally has cytoplasmic clearing (due to glycogen).<ref name=PST14feb11>PST. 14 February 2011.</ref> | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Ewing_sarcoma_-_very_high_mag.jpg | ES - very high mag. (WC) | |||
Image:Ewing_sarcoma_-_PAS_-_very_high_mag.jpg | ES - PAS - very high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case103.html Ewing sarcoma - case 1 - several images (upmc.edu)]. | |||
*[http://path.upmc.edu/cases/case420.html Ewing sarcoma - case 2 - several images (upmc.edu)]. | |||
===[[IHC]]=== | ===[[IHC]]=== | ||
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*Large (multinucleated) osteoclast-like giant cells may be seen.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref> | *Large (multinucleated) osteoclast-like giant cells may be seen.<ref>{{cite journal |author=Papalas JA, Balmer NN, Wallace C, Sangueeza OP |title=Ossifying dermatofibroma with osteoclast-like giant cells: report of a case and literature review |journal=Am J Dermatopathol |volume=31 |issue=4 |pages=379-83 |year=2009 |month=June |pmid=19461244 |doi=10.1097/DAD.0b013e3181966747 |url=}}</ref> | ||
Images | =====Images===== | ||
<gallery> | |||
Image:Osteosarcoma_-_intermed_mag.jpg | Osteosarcoma - intermed. mag. (WC) | |||
Image:Osteosarcoma_-_very_high_mag.jpg | Osteosarcoma - very high mag. (WC) | |||
Image:Small_cell_osteosarcoma_-_intermed_mag.jpg | Small cell osteosarcoma - intermed. mag. (WC) | |||
Image:Small_cell_osteosarcoma_-_high_mag.jpg | Small cell osteosarcoma - high mag. (WC) | |||
</gallery> | |||
====Subtypes==== | ====Subtypes==== | ||
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**[[Aneurysmal bone cyst]] - typically has spindle cells around the giant cells. | **[[Aneurysmal bone cyst]] - typically has spindle cells around the giant cells. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Giant_cell_tumour_of_bone_-_high_mag.jpg | GCT of bone - high mag. (WC) | |||
Image:Giant_cell_tumour_of_bone_-_low_mag.jpg | GCT of bone - low mag. (WC) | |||
</gallery> | |||
===IHC=== | ===IHC=== | ||
*p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal |author=Dickson BC, Li SQ, Wunder JS, ''et al.'' |title=Giant cell tumor of bone express p63 |journal=Mod. Pathol. |volume=21 |issue=4 |pages=369–75 |year=2008 |month=April |pmid=18311114 |doi=10.1038/modpathol.2008.29 |url=}}</ref> | *p63 +ve in scattered mononuclear cells.<ref name=pmid18311114>{{cite journal |author=Dickson BC, Li SQ, Wunder JS, ''et al.'' |title=Giant cell tumor of bone express p63 |journal=Mod. Pathol. |volume=21 |issue=4 |pages=369–75 |year=2008 |month=April |pmid=18311114 |doi=10.1038/modpathol.2008.29 |url=}}</ref> | ||
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*Foam cells. | *Foam cells. | ||
Images | ====Images==== | ||
<gallery> | |||
Image:Pigmented_villonodular_synovitis_low_mag.jpg | PVNS - low mag. (WC) | |||
Image:Pigmented_villonodular_synovitis_high_mag.jpg | PVNS - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://path.upmc.edu/cases/case251/micro.html PVNS - several images (upmc.edu)]. | |||
==Giant cell tumour of tendon sheath== | ==Giant cell tumour of tendon sheath== | ||
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*#Fibrous/spindle cell component. | *#Fibrous/spindle cell component. | ||
*#Epithelial component. | *#Epithelial component. | ||
DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref> | DDx:<ref name=pathcon_adam>URL: [http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2 http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970057-2]. Accessed on: 28 April 2011.</ref> | ||
*Vascular tumours ([[Epithelioid hemangioendothelioma]]). | *Vascular tumours ([[Epithelioid hemangioendothelioma]]). | ||
*Metastatic carcinoma. | *Metastatic carcinoma. | ||
====Images==== | |||
<gallery> | |||
Image:Adamantinoma_-_intermed_mag.jpg | Adamantinoma - intermed. mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://southbaypath.org/CaseImages/sb5260/AdamantinomaBiopsy3.jpg Adamantinoma (southbaypath.org)].<ref>URL: [http://southbaypath.org/CaseImages/sb5260/sb5260.htm http://southbaypath.org/CaseImages/sb5260/sb5260.htm]. Accessed on: 7 December 2010.</ref> | |||
===IHC=== | ===IHC=== | ||
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*[[Giant cell tumour of bone]] and other [[giant cell lesions]]. | *[[Giant cell tumour of bone]] and other [[giant cell lesions]]. | ||
Images: | ====Images==== | ||
<gallery> | |||
Image:Brown_tumour_-_low_mag.jpg | Brown tumour - low mag. (WC) | |||
Image:Brown_tumour_-_intermed_mag.jpg | Brown tumour - intermed. mag. (WC) | |||
Image:Brown_tumour_-_high_mag.jpg | Brown tumour - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://wwwold.path.utah.edu/classes/webpath/bonehtml/bone053.htm Brown tumour (utah.edu)]. | |||
*[http://www.mda-sy.com/pathology/BONEHTML/BONE054.HTM Brown tumour (mda-sy.com)]. | |||
*[http://path.upmc.edu/cases/case139/micro.html Brown tumour - several images (upmc.edu)]. | |||
=See also= | =See also= | ||