Difference between revisions of "Desmoplasia"

Desmoplasia (view source)

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-'''Desmoplasia''', also '''desmoplastic response''' and '''desmoplastic stromal response''', is a stromal change associated with [[cancer]].  It is a finding that in the context of dysplasia supports a diagnosis of invasion.
+'''Desmoplasia''' is the formation if fibrous connective tissue.<ref>URL: [http://www.merriam-webster.com/medical/desmoplasia http://www.merriam-webster.com/medical/desmoplasia]. Accessed on: 2 May 2013.</ref> It is also known as the '''desmoplastic response''' and '''desmoplastic stromal response'''.
+It is a stromal change that in the context of dysplasia supports the diagnosis of invasive carcinoma.
 ==Microscopic==
-Feature:<ref>{{Ref TPoSP|15}}</ref>
+Feature:
-*Large (plump) spindle cells with relatively pale nuclei.
+*Increased stromal cellularity - '''key feature'''.
-*Increased cellular density.
+**Large (plump) spindle cells with relatively pale nuclei.
-*Edema - pale spaces between the cells.
+*Edema - pale spaces between the cells - may be apparent at low power.<ref>{{Ref TPoSP|15}}</ref>
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 ==See also==
 *[[Pseudoinvasion]].
+*[[Cancer]].
+*[[Basics]].
 ==References==