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Difference between revisions of "Stomach"
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→Neoplastic: dirty merge of 'adenomatous polyp' and 'gastric columnar dysplasia'
(→Neoplastic: dirty merge of 'adenomatous polyp' and 'gastric columnar dysplasia') |
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#Gastric carcinoma. | #Gastric carcinoma. | ||
== | ==Gastric dysplasia== | ||
:''Gastric adenoma'' directs here. | |||
*[[AKA]] ''gastric columnar dysplasia''. | |||
===General=== | |||
*Lesions that protrude into the lumen ''and'' are discrete macroscopically are known as: ''adenomas''.:<ref name=pmid10680883>{{Cite journal | last1 = Rugge | first1 = M. | last2 = Correa | first2 = P. | last3 = Dixon | first3 = MF. | last4 = Hattori | first4 = T. | last5 = Leandro | first5 = G. | last6 = Lewin | first6 = K. | last7 = Riddell | first7 = RH. | last8 = Sipponen | first8 = P. | last9 = Watanabe | first9 = H. | title = Gastric dysplasia: the Padova international classification. | journal = Am J Surg Pathol | volume = 24 | issue = 2 | pages = 167-76 | month = Feb | year = 2000 | doi = | PMID = 10680883 }}</ref> | |||
*Polypoid forms are grouped various ways.<ref name=pmid18384215>{{Cite journal | last1 = Park | first1 = do Y. | last2 = Lauwers | first2 = GY. | title = Gastric polyps: classification and management. | journal = Arch Pathol Lab Med | volume = 132 | issue = 4 | pages = 633-40 | month = Apr | year = 2008 | doi = 10.1043/1543-2165(2008)132[633:GPCAM]2.0.CO;2 | PMID = 18384215 | url=http://www.archivesofpathology.org/doi/full/10.1043/1543-2165(2008)132%5B633:GPCAM%5D2.0.CO;2 }}</ref> | |||
====Grading==== | |||
Like in the colon - they are divided into: | |||
*Low grade. | |||
*High grade. | |||
====Subclassification==== | |||
One subclassification:<ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/gastric-adenoma/printable.html http://surgpathcriteria.stanford.edu/gitumors/gastric-adenoma/printable.html]. Accessed on: 18 December 2012.</ref> | |||
*Intestinal: goblet cells or Paneth cells. | |||
**Not associated with FAP. | |||
*Gastric: foveolar epithelium. | |||
**Associated with [[familial adenomatous polyposis]] (FAP). | |||
===Microscopic=== | ===Microscopic=== | ||
====Foveolar type | *Histologic criteria similar to columnar dysplasia in the [[esophagus]]. | ||
**The threshold is much lower than in the colon and rectum. | |||
====Foveolar type==== | |||
Features: | Features: | ||
*Hyperchromasia at the surface - '''key feature'''. | *Hyperchromasia at the surface - '''key feature'''. | ||
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*[[Reactive changes]]. | *[[Reactive changes]]. | ||
====Intestinal type | ====Intestinal type==== | ||
Features - intestinal: | Features - intestinal: | ||
*[[Intestinal metaplasia of the stomach|Intestinal metaplasia]]. | *[[Intestinal metaplasia of the stomach|Intestinal metaplasia]]. | ||
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*[http://www.sciencedirect.com/science/article/pii/S1756231710001878 Gastric polyps - several images (sciencedirect.com)]. | *[http://www.sciencedirect.com/science/article/pii/S1756231710001878 Gastric polyps - several images (sciencedirect.com)]. | ||
*[http://www.archivesofpathology.org/doi/pdf/10.1043/1543-2165%282008%29132%5B633%3AGPCAM%5D2.0.CO%3B2 Gastric polyps - several images (achivesofpathology.org)]. | *[http://www.archivesofpathology.org/doi/pdf/10.1043/1543-2165%282008%29132%5B633%3AGPCAM%5D2.0.CO%3B2 Gastric polyps - several images (achivesofpathology.org)]. | ||
====Grading==== | ====Grading==== | ||
=====Low-grade gastric dysplasia===== | |||
====Low-grade gastric | |||
Features: | Features: | ||
*Nuclear changes: | *Nuclear changes: | ||
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*[http://path.upmc.edu/cases/case431.html Low-grade gastric columnar dysplasia - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case431.html Low-grade gastric columnar dysplasia - several images (upmc.edu)]. | ||
====High-grade gastric | =====High-grade gastric dysplasia===== | ||
Features: | Features: | ||
*Nuclear changes: | *Nuclear changes: | ||