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Difference between revisions of "Lymph nodes"
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'''Lymph nodes''', abbreviated '''LNs''', are very important in pathology. They are the site of [[metastases]] and/or may be the site of a primary tumour, i.e. [[lymphoma]]. | '''Lymph nodes''', abbreviated '''LNs''', are very important in pathology. They are the site of [[metastases]] and/or may be the site of a primary tumour, i.e. [[lymphoma]]. | ||
Haematopathology and lymphoma is dealt with in the ''[[haematopathology]]'' article. This article covers the basics of lymph nodes. Lymph node pathology is dealt with in the ''[[lymph node pathology]]'' article. | Haematopathology and lymphoma is dealt with in the ''[[haematopathology]]'' article. This article covers the basics of lymph nodes. Lymph node pathology is dealt with in the ''[[lymph node pathology]]'' article. [[Grossing]] is covered in ''[[lymph node grossing]]''. | ||
=Clinical= | =Clinical= | ||
| Line 23: | Line 23: | ||
=Gross pathologic exam= | =Gross pathologic exam= | ||
{{Main|Lymph node grossing}} | |||
Normal: | Normal: | ||
*Firm (relative to adipose tissue). | *Firm (relative to adipose tissue). | ||
| Line 159: | Line 160: | ||
| mesh-like chromatin, usu. beside another one | | mesh-like chromatin, usu. beside another one | ||
| large cell, unremarkable/small nucleolus | | large cell, unremarkable/small nucleolus | ||
| CD21+, CD23+ | | CD21+, [[CD23]]+ | ||
| other ? | | other ? | ||
| image ? | | image ? | ||
| Line 189: | Line 190: | ||
*LN sampling is associated with morbidity; thus, selective LN sampling is preferred. | *LN sampling is associated with morbidity; thus, selective LN sampling is preferred. | ||
*The most important LNs in a LN chain, in the context of [[cancer]], are the ones that are adjacent to the tumour; these are known as '''sentinel lymph nodes'''. | *The most important LNs in a LN chain, in the context of [[cancer]], are the ones that are adjacent to the tumour; these are known as '''sentinel lymph nodes'''. | ||
*In lymph node positive disease, the most radioactive lymph node may be negative; this happens ~13% of the time in melanoma.<ref name=pmid11314933>{{Cite journal | last1 = McMasters | first1 = KM. | last2 = Reintgen | first2 = DS. | last3 = Ross | first3 = MI. | last4 = Wong | first4 = SL. | last5 = Gershenwald | first5 = JE. | last6 = Krag | first6 = DN. | last7 = Noyes | first7 = RD. | last8 = Viar | first8 = V. | last9 = Cerrito | first9 = PB. | title = Sentinel lymph node biopsy for melanoma: how many radioactive nodes should be removed? | journal = Ann Surg Oncol | volume = 8 | issue = 3 | pages = 192-7 | month = Apr | year = 2001 | doi = | PMID = 11314933 }}</ref> | |||
Use: | Use: | ||
*[[Sentinel lymph node sampling in breast cancer|Breast cancer]] - very common. | *[[Sentinel lymph node sampling in breast cancer|Breast cancer]] - very common. | ||
*[[Malignant melanoma#Sentinel lymph node panel|Malignant melanoma]] - first context in which SLN sampling was done. | *[[Malignant melanoma#Sentinel lymph node panel|Malignant melanoma]] - first context in which SLN sampling was done. | ||
===Lymph node metastasis=== | |||
{{Main|Lymph node metastasis}} | |||
*Cancer that has spread to a lymph node. | |||
=See also= | =See also= | ||