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Difference between revisions of "Urothelium"
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The '''urothelium''' lines the upper portion of the genitourinary tract, i.e. [[ureter]]s, [[urinary bladder]]), and a bit of the lower part. | The '''urothelium''' lines the upper portion of the genitourinary tract, i.e. [[ureter]]s, [[urinary bladder]]), and a bit of the lower part. | ||
=Normal | =Normal urothelium= | ||
==Gross== | |||
===Extent of urothelium=== | |||
==Extent of urothelium== | |||
*[[Ureters]]. | *[[Ureters]]. | ||
*Renal pelvis. | *Renal pelvis. | ||
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*Part of the urethra. | *Part of the urethra. | ||
===Urethra in males=== | ====Urethra in males==== | ||
*Pre-prostatic urethra - transitional epithelium. | *Pre-prostatic urethra - transitional epithelium. | ||
*[[Prostate gland|Prostatic]] urethra - transitional epithelium. | *[[Prostate gland|Prostatic]] urethra - transitional epithelium. | ||
*Membranous urethra (from apex of prostate to bulb of penis (bulb of the corpus spongiosusm)) - pseudostratified columnar epithelium. | *Membranous urethra (from apex of prostate to bulb of penis (bulb of the corpus spongiosusm)) - pseudostratified columnar epithelium. | ||
*Spongy urethra - pseudostratified columnar epithelium (proximal) & stratified squamous (distal). | *Spongy urethra - pseudostratified columnar epithelium (proximal) & stratified squamous (distal). | ||
==Microscopic== | |||
Features: | |||
*Maturation (cuboidal at base - squamoid at surface). | |||
**Surface cells called 'umbrella cells' (umbrella cells CK20 +ve). | |||
*Urothelium should be 4-5 cell layers thick. | |||
*+/-Prominent [[nucleoli]]. | |||
Note: | |||
*Should '''not''' have a papillary architecture -- if it does it is likely [[cancer]]! | |||
**If it is 'papillary' -- it must have fibrovascular cores. | |||
==Sign out== | |||
<pre> | |||
URINARY BLADDER LESION ("TUMOUR"), TRANSURETHRAL RESECTION URINARY BLADDER TUMOUR (TURBT): | |||
- UROTHELIAL MUCOSA WITHIN NORMAL LIMITS. | |||
- NEGATIVE FOR MALIGNANCY. | |||
</pre> | |||
=Approach= | =Approach= | ||