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Difference between revisions of "Prostate cancer"
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→Gleason pattern 5: tweak
(→Gleason pattern 5: tweak) |
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====Gleason pattern 5==== | ====Gleason pattern 5==== | ||
*Sheets. | *Sheets. | ||
**Must be differentiated from intraductal growth (which like in the breast are well circumscribed nests). | **Must be differentiated from [[intraductal carcinoma of the prostate|intraductal growth]] (which like in the breast are well circumscribed nests). | ||
*Single cells. | *Single cells. | ||
**May be confused with stromal/lymphocytic infiltration. | **May be confused with stromal/lymphocytic infiltration. | ||
| Line 235: | Line 235: | ||
**Line of cells. | **Line of cells. | ||
**Should not be intermixed with clumps of cells (pattern 4). | **Should not be intermixed with clumps of cells (pattern 4). | ||
*Nests of cells with [[necrosis]] at centre (comedonecrosis). | *Nests of cells with [[necrosis]] (at the centre) (comedonecrosis) ''or'' (intraluminal) necrosis in a cribriform pattern.<ref name=pmid16096414/> | ||
**Necrosis: | |||
***Nuclear changes: | |||
****Karyorrhexis (nuclear fragmentation). | |||
****Pynosis (nuclear shrinkage). | |||
****Karyolysis (nuclear dissolution). | |||
***Cell ghosts (cells without a nucleus). | |||
Notes: | Notes: | ||