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Difference between revisions of "Prostate cancer"
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→Gleason grading system: tweak
(→Gleason grading system: tweak) |
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*Adenosquamous carcinoma. | *Adenosquamous carcinoma. | ||
*Adenoid cystic carcinoma. | *Adenoid cystic carcinoma. | ||
====Biopsy-prostatectomy concordance of Gleason score==== | |||
*Discordance is common. | |||
**Upgrade on prostatectomy: 25-40%. | |||
**Downgrade on prostatectomy: 5-15%. | |||
Selected studies on concordance: | |||
{| class="wikitable sortable" style="margin-left:auto;margin-right:auto" | |||
! Study | |||
! Upgrade | |||
! Downgrade | |||
! Notes | |||
|- | |||
| Sfoungaristos et al.<ref name=pmid22277633>{{Cite journal | last1 = Sfoungaristos | first1 = S. | last2 = Perimenis | first2 = P. | title = Clinical and pathological variables that predict changes in tumour grade after radical prostatectomy in patients with prostate cancer. | journal = Can Urol Assoc J | volume = | issue = | pages = 1-5 | month = Jan | year = 2012 | doi = 10.5489/cuaj.11067 | PMID = 22277633 }}</ref> | |||
| 42.1% | |||
| 13.7% | |||
| high volume of tumour predicts upgrade | |||
|- | |||
| Thomas et al.<ref name=pmid21592293>{{Cite journal | last1 = Thomas | first1 = C. | last2 = Pfirrmann | first2 = K. | last3 = Pieles | first3 = F. | last4 = Bogumil | first4 = A. | last5 = Gillitzer | first5 = R. | last6 = Wiesner | first6 = C. | last7 = Thüroff | first7 = JW. | last8 = Melchior | first8 = SW. | title = Predictors for clinically relevant Gleason score upgrade in patients undergoing radical prostatectomy. | journal = BJU Int | volume = 109 | issue = 2 | pages = 214-9 | month = Jan | year = 2012 | doi = 10.1111/j.1464-410X.2011.10187.x | PMID = 21592293 }}</ref> | |||
| 38.1% | |||
| 4.7% | |||
| | |||
|- | |||
| Truesdale et al.<ref name=pmid20840549>{{Cite journal | last1 = Truesdale | first1 = MD. | last2 = Cheetham | first2 = PJ. | last3 = Turk | first3 = AT. | last4 = Sartori | first4 = S. | last5 = Hruby | first5 = GW. | last6 = Dinneen | first6 = EP. | last7 = Benson | first7 = MC. | last8 = Badani | first8 = KK. | title = Gleason score concordance on biopsy-confirmed prostate cancer: is pathological re-evaluation necessary prior to radical prostatectomy? | journal = BJU Int | volume = 107 | issue = 5 | pages = 749-54 | month = Mar | year = 2011 | doi = 10.1111/j.1464-410X.2010.09570.x | PMID = 20840549 }}</ref> | |||
| 23% | |||
| 11% | |||
| | |||
|} | |||
===Staging parameters and margins=== | ===Staging parameters and margins=== | ||