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Difference between revisions of "Prostate cancer"
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m
→Microscopic
(→Intraductal carcinoma of the prostate: add criteria) |
m (→Microscopic) |
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===Microscopic=== | ===Microscopic=== | ||
====Major criteria==== | ====Major criteria==== | ||
Required major criteria:<ref name=pmid22692290>{{Cite journal | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref> | Required major criteria:<ref name=pmid22692290>{{Cite journal | last1 = Shah | first1 = RB. | last2 = Zhou | first2 = M. | title = Atypical cribriform lesions of the prostate: clinical significance, differential diagnosis and current concept of intraductal carcinoma of the prostate. | journal = Adv Anat Pathol | volume = 19 | issue = 4 | pages = 270-8 | month = Jul | year = 2012 | doi = 10.1097/PAP.0b013e31825c6c0e | PMID = 22692290 }}</ref><ref name=pmid17616999>{{Cite journal | last1 = Cohen | first1 = RJ. | last2 = Wheeler | first2 = TM. | last3 = Bonkhoff | first3 = H. | last4 = Rubin | first4 = MA. | title = A proposal on the identification, histologic reporting, and implications of intraductal prostatic carcinoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 7 | pages = 1103-9 | month = Jul | year = 2007 | doi = 10.1043/1543-2165(2007)131[1103:APOTIH]2.0.CO;2 | PMID = 17616999 }}</ref> | ||
#Glands 2x normal (peripheral zone) glands. | #Glands 2x normal (peripheral zone) glands. | ||
#Basal cell present (proven by IHC). | #Basal cell present (proven by IHC). | ||
| Line 501: | Line 501: | ||
#*Solid = no spaces between the cells. | #*Solid = no spaces between the cells. | ||
Additional (major) | Additional (major) criterion:<ref name=pmid22692290/> | ||
*Comedo[[necrosis]]. | *Comedo[[necrosis]]. | ||
| Line 509: | Line 509: | ||
#Rounded/smooth gland outlines. | #Rounded/smooth gland outlines. | ||
#Two cell populations: | #Two cell populations: | ||
#* | #*Malignant population (enlarged nuclei with hyperchromasia and nucleoli) = peripheral location in gland. | ||
#* | #*Benign population (smaller nuclei, no nucleoli) = central location in gland. | ||
DDx: | DDx: | ||