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Difference between revisions of "An introduction to head and neck pathology"
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An introduction to head and neck pathology (view source)
Revision as of 13:42, 12 November 2012
, 13:42, 12 November 2012→Leukoplakia
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===General=== | ===General=== | ||
*Non-specific clinical finding - may be benign or malignant. | *Non-specific clinical finding - may be benign ''or'' malignant. | ||
*Associated with tobacco use.<ref name=pmid11336117>{{Cite journal | last1 = Bánóczy | first1 = J. | last2 = Gintner | first2 = Z. | last3 = Dombi | first3 = C. | title = Tobacco use and oral leukoplakia. | journal = J Dent Educ | volume = 65 | issue = 4 | pages = 322-7 | month = Apr | year = 2001 | doi = | PMID = 11336117 }}</ref> | *Associated with tobacco use.<ref name=pmid11336117>{{Cite journal | last1 = Bánóczy | first1 = J. | last2 = Gintner | first2 = Z. | last3 = Dombi | first3 = C. | title = Tobacco use and oral leukoplakia. | journal = J Dent Educ | volume = 65 | issue = 4 | pages = 322-7 | month = Apr | year = 2001 | doi = | PMID = 11336117 }}</ref> | ||
*In twos series ~13% were associated with an invasive lesion.<ref name=pmid19953947>{{Cite journal | last1 = Lan | first1 = AX. | last2 = Guan | first2 = XB. | last3 = Sun | first3 = Z. | title = [Analysis of risk factors for carcinogenesis of oral leukoplakia]. | journal = Zhonghua Kou Qiang Yi Xue Za Zhi | volume = 44 | issue = 6 | pages = 327-31 | month = Jun | year = 2009 | doi = | PMID = 19953947 }}</ref><ref name=pmid16545712>{{Cite journal | last1 = Lee | first1 = JJ. | last2 = Hung | first2 = HC. | last3 = Cheng | first3 = SJ. | last4 = Chen | first4 = YJ. | last5 = Chiang | first5 = CP. | last6 = Liu | first6 = BY. | last7 = Jeng | first7 = JH. | last8 = Chang | first8 = HH. | last9 = Kuo | first9 = YS. | title = Carcinoma and dysplasia in oral leukoplakias in Taiwan: prevalence and risk factors. | journal = Oral Surg Oral Med Oral Pathol Oral Radiol Endod | volume = 101 | issue = 4 | pages = 472-80 | month = Apr | year = 2006 | doi = 10.1016/j.tripleo.2005.07.024 | PMID = 16545712 }}</ref> | |||
**Non-homogenous leukoplakia has a greater risk of malignancy than homogenous.<ref name=pmid16545712/> | |||
===Gross=== | |||
*White lesion - may be subdivided: | |||
**Non-homogenous. | |||
**Homogenous. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=Ref_PBoD780>{{Ref PBoD|780}}</ref> | Features:<ref name=Ref_PBoD780>{{Ref PBoD|780}}</ref> | ||
*Often associated with epithelial thickening ([[hyperkeratosis]], acanthosis). | *Often associated with epithelial thickening ([[hyperkeratosis]], acanthosis). | ||
DDx: | DDx: | ||