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Difference between revisions of "Colon"
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→Pseudomelanosis coli: tweak
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*''Not melanin'' as the name ''melanosis coli'' suggests; it is actually lipofuscin (in macrophages).<ref name=pmid18666316>{{cite journal |author=Freeman HJ |title="Melanosis" in the small and large intestine |journal=World J. Gastroenterol. |volume=14 |issue=27 |pages=4296-9 |year=2008 |month=July |pmid=18666316 |doi= |url=http://www.wjgnet.com/1007-9327/14/4296.asp}}</ref> | *''Not melanin'' as the name ''melanosis coli'' suggests; it is actually lipofuscin (in macrophages).<ref name=pmid18666316>{{cite journal |author=Freeman HJ |title="Melanosis" in the small and large intestine |journal=World J. Gastroenterol. |volume=14 |issue=27 |pages=4296-9 |year=2008 |month=July |pmid=18666316 |doi= |url=http://www.wjgnet.com/1007-9327/14/4296.asp}}</ref> | ||
*Endoscopist may see brown pigmentation of mucosa and suspect the diagnosis. | *Endoscopist may see brown pigmentation of mucosa and suspect the diagnosis. | ||
*Presence may lead to endoscopic misinterpretation of colitis severity.<ref name=pmid21375218>{{Cite journal | last1 = Zapatier | first1 = JA. | last2 = Schneider | first2 = A. | last3 = Parra | first3 = JL. | title = Overestimation of ulcerative colitis due to melanosis coli. | journal = Acta Gastroenterol Latinoam | volume = 40 | issue = 4 | pages = 351-3 | month = Dec | year = 2010 | doi = | PMID = 21375218 }}</ref> | |||
====Epidemiology==== | ====Epidemiology==== | ||
*Classically associated with anthracene containing laxative (e.g. Senokot) use and herbal remedies.<ref name=pmid18666316/> | *Classically associated with anthracene containing laxative (e.g. Senokot) use and herbal remedies.<ref name=pmid18666316/> | ||
**May be seen in individuals not using laxatives.<ref name=pmid9600362/> | |||
*Seen in (long-standing) [[inflammatory bowel disease]], especially [[ulcerative colitis]].<ref name=pmid9600362>{{Cite journal | last1 = Pardi | first1 = DS. | last2 = Tremaine | first2 = WJ. | last3 = Rothenberg | first3 = HJ. | last4 = Batts | first4 = KP. | title = Melanosis coli in inflammatory bowel disease. | journal = J Clin Gastroenterol | volume = 26 | issue = 3 | pages = 167-70 | month = Apr | year = 1998 | doi = | PMID = 9600362 }}</ref> | |||
===Gross=== | ===Gross=== | ||
*Brown pigmentation of the mucosa. | *Brown pigmentation of the mucosa, esp. cecum and proximal colon. | ||
Image: | Image: | ||