Difference between revisions of "Duodenum"

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[[Image:Duodenumanatomy.jpg|thumb|Schematic of the duodenum. (WC/Luke Guthmann)]]
The '''duodenum''' is the first part of the [[small bowel]] and receives food from the [[stomach]].  It is accessible by EGD (esophagogastroduodenoscopy) and frequently biopsied.   
The '''duodenum''' is the first part of the [[small bowel]] and receives food from the [[stomach]].  It is accessible by EGD (esophagogastroduodenoscopy) and frequently biopsied.   


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=Getting started=
=Getting started=
===Normal duodenum===
==Normal duodenum==
*Abbreviated ''ND''.
===General===
*Very common.
 
===Microscopic===
*Three tall villi.
*Three tall villi.
*Few intraepithelial lymphocytes; < 1 lymphocyte / 4 epithelial cells.
*Few intraepithelial lymphocytes; < 1 lymphocyte / 4 epithelial cells.
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*No organisms in lumen.
*No organisms in lumen.


===Basic DDx===
DDx:
*[[Intestinal metaplasia of the stomach]] - foveolar epithelium + other histologic components of the stomach.
*[[Chronic duodenitis]] - foveolar epithelium, [[Brunner's gland hyperplasia]].
 
===Sign out===
<pre>
Duodenum, Biopsy:
- Small bowel mucosa and Brunner's glands within normal limits.</pre>
 
<pre>
Duodenum, Biopsy:
- Small bowel mucosa within normal limits.
</pre>
 
<pre>
Duodenum, Biopsy:
- Small bowel mucosa within normal limits.
- NEGATIVE for findings suggestive of celiac disease.
</pre>
 
<pre>
Small Bowel (Duodenum), Biopsy:
- Small bowel mucosa within normal limits.
- NEGATIVE for findings suggestive of celiac disease.
</pre>
 
====Block letters====
<pre>
DUODENUM, BIOPSY:
- SMALL BOWEL MUCOSA AND BRUNNER'S GLANDS WITHIN NORMAL LIMITS.
</pre>
 
<pre>
DUODENUM, BIOPSY:
- SMALL BOWEL MUCOSA WITHIN NORMAL LIMITS.
</pre>
 
<pre>
DUODENUM, BIOPSY:
- SMALL BOWEL MUCOSA WITHIN NORMAL LIMITS.
- NEGATIVE FOR FINDINGS SUGGESTIVE OF CELIAC DISEASE.
</pre>
 
<pre>
SMALL BOWEL (DUODENUM), BIOPSY:
- SMALL BOWEL MUCOSA WITHIN NORMAL LIMITS.
- NEGATIVE FOR FINDINGS SUGGESTIVE OF CELIAC DISEASE.
</pre>
 
==Basic DDx==
*Celiac sprue.
*Celiac sprue.
**Intraepithelial lymphocytes - '''key feature'''.
**Intraepithelial lymphocytes - '''key feature'''.
**Loss of villi.
**Loss of villi.
*Giarrdia.
*Giardia.
**Like celiac... but giarrdia organisms.
**Like celiac... but giardia organisms.
*Adenomas.
*Adenomas.
**Too much blue - similar to colonic adenomas.
**Too much blue - similar to colonic adenomas.
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**Too much blue and epithelium in the wrong place.
**Too much blue and epithelium in the wrong place.
====More====
====More====
*H. pylori only in areas of gastric metaplasia.<ref>El-Zimaity. 18 October 2010.</ref>
*[[Helicobacter duodenitis|H. pylori]] only in areas of [[Gastric heterotopia of the duodenum|gastric metaplasia]].<ref>El-Zimaity. 18 October 2010.</ref>


===Duodenal nodules DDX===
===Duodenal nodules DDX===
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{{familytree | | | | | B01 | | | | | | | | | | | | | | B02 | | | | | | | | | | | | |B01=Benign<br>(common)| B02=Neoplastic}}
{{familytree | | | | | B01 | | | | | | | | | | | | | | B02 | | | | | | | | | | | | |B01=Benign<br>(common)| B02=Neoplastic}}
{{familytree | |,|-|-|-|+|-|-|-|.| | | |,|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|.| | | | | |}}
{{familytree | |,|-|-|-|+|-|-|-|.| | | |,|-|-|-|v|-|-|-|+|-|-|-|v|-|-|-|.| | | | | |}}
{{familytree | C01 | | C02 | | C03 | | C04 | | C05 | | C06 | | C07 | | C08 | | | | |C01=Brunner's<br>gland|C02=Heterotopic<br>gastric mucosa|C03=Lymphoid<br>nodule|C04=Adenoma|C05=[[Neuroendocrine tumour|NET]]|C06=[[Paraganglioma]]|C07=Prolapsed<br>gastric polyp|C08=[[Metastasis]]}}
{{familytree | C01 | | C02 | | C03 | | C04 | | C05 | | C06 | | C07 | | C08 | | | | |C01=Brunner's<br>gland|C02=[[Gastric heterotopia of the duodenum|Heterotopic<br>gastric mucosa]]|C03=Lymphoid<br>nodule|C04=Adenoma|C05=[[Neuroendocrine tumour|NET]]|C06=[[Paraganglioma]]|C07=Prolapsed<br>gastric polyp|C08=[[Metastasis]]}}
{{familytree/end}}
{{familytree/end}}


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=Common stuffs=
=Common stuffs=
==Gastric heterotopia of the duodenum==
*[[AKA]] ''heterotopic gastric mucosa''.
{{Main|Gastric heterotopia of the duodenum}}
==Celiac sprue==
==Celiac sprue==
*[[AKA]] ''celiac disease''.
{{main|Celiac sprue}}
{{main|Celiac sprue}}
===General===
*Etiology: autoimmune.


====Epidemiology====
==Giardiasis==
*Associated with:
{{Main|Giardiasis}}
**The skin condition ''[[dermatitis herpetiformis]]''.<ref>TN 2007 D22</ref>
 
**IgA deficiency - 10-15X more common in celiac disease vs. healthy controls.<ref name=pmid12414763>{{Cite journal  | last1 = Kumar | first1 = V. | last2 = Jarzabek-Chorzelska | first2 = M. | last3 = Sulej | first3 = J. | last4 = Karnewska | first4 = K. | last5 = Farrell | first5 = T. | last6 = Jablonska | first6 = S. | title = Celiac disease and immunoglobulin a deficiency: how effective are the serological methods of diagnosis? | journal = Clin Diagn Lab Immunol | volume = 9 | issue = 6 | pages = 1295-300 | month = Nov | year = 2002 | doi =  | PMID = 12414763 }}</ref>
==Acute duodenitis==
**Risk factor for ''gastrointestinal T cell lymphoma'' - known as: ''enteropathy-associated T cell lymphoma'' (EATL).
*Abbreviated ''AD''.
{{Main|Acute duodenitis}}


====Clinical====
==Chronic duodenitis==
Treatment:
===General===
*Gluten free diet.
*This is not very well defined as [[plasma cell]]s are present in a normal duodenum.
**''Mnemonic'': BROW = barley, rye, oats, wheat.


Serologic testing:
===Gross===
*Anti-transglutaminase antibody.
*Duodenal erythema.
**Alternative test: anti-endomysial antibody.
*IgA -- assoc. with celiac sprue.


===Microscopic===
===Microscopic===
Features:<ref name=Ref_PBoD843>{{Ref PBoD|843}}</ref>
Features:
*Intraepithelial lymphocytes (IELs) - '''key feature'''.
*"Abundant" lamina propria plasma cells.
**Should be more pronounced at tips of villi.<ref name=pmid15280404>{{cite journal |author=Biagi F, Luinetti O, Campanella J, ''et al.'' |title=Intraepithelial lymphocytes in the villous tip: do they indicate potential coeliac disease? |journal=J. Clin. Pathol. |volume=57 |issue=8 |pages=835–9 |year=2004 |month=August |pmid=15280404 |pmc=1770380 |doi=10.1136/jcp.2003.013607 |url=}}</ref>
*Villous blunting.
**Criteria for number varies:
*[[Brunner's gland hyperplasia]].
*** > 40 IELs / 100 enterocytes (epithelial cells).<ref name=pmid10524652>{{cite journal |author=Oberhuber G, Granditsch G, Vogelsang H |title=The histopathology of coeliac disease: time for a standardized report scheme for pathologists |journal=Eur J Gastroenterol Hepatol |volume=11 |issue=10 |pages=1185–94 |year=1999 |month=October |pmid=10524652 |doi= |url=}}</ref>
*** > 25 IELs / 100 enterocytes (epithelial cells).<ref name=pmid17544877>{{cite journal |author=Corazza GR, Villanacci V, Zambelli C, ''et al.'' |title=Comparison of the interobserver reproducibility with different histologic criteria used in celiac disease |journal=Clin. Gastroenterol. Hepatol. |volume=5 |issue=7 |pages=838–43 |year=2007 |month=July |pmid=17544877 |doi=10.1016/j.cgh.2007.03.019 |url=}}</ref>
*Loss of villi - '''important feature'''.
**Normal duodenal biopsy should have 3 good villi.
*Plasma cells - abundant (weak feature).
*Macrophages.
*Mitosis increased (in the crypts).
*+/-Collagen band (pink material in mucosa) - "Collagenous sprue"; must encompass ~25% of mucosa.


Image:
DDx:
*[http://commons.wikimedia.org/wiki/File:Coeliac_path.jpg Celiac sprue (WC)].
*[[Normal duodenum]].


Notes:  
===Sign out===
*If you see acute inflammatory cells, i.e. neutrophils, consider Giardiasis and other infectious etiologies.
<pre>
*Biopsy should consist of 2-3 sites.  In children it is important to sample the duodenal cap, as it is the only affected site in ~10% of cases.
DUODENUM, BIOPSY:
*Flat lesions without IELs are unlikely to be celiac sprue.
- MODERATE NON-SPECIFIC CHRONIC DUODENTIS (SMALL BOWEL MUCOSA WITH VILLOUS
*Mucosa erosions are rare in celiac sprue; should prompt consideration of an alternate diagnosis (infection, medications, Crohn's disease).
  BLUNTING, PROMINENT BRUNNER'S GLANDS, ABUNDANT LAMINA PROPRIA PLASMA CELLS
  AND OCCASIONAL INTRAEPITHELIAL LYMPHOCYTES, WITHOUT FOVEOLAR METAPLASIA).
- NEGATIVE FOR DYSPLASIA.
</pre>


===Grading===
==Peptic duodenitis==
Rarely done - see ''[[celiac sprue]]'' article.
{{Main|Peptic duodenitis}}


==Giardiasis==
==Brunner's gland hyperplasia==
:''Brunner's gland hamartoma'' redirects here.
*Abbreviated ''BGH''.
*[[AKA]] ''Brunneroma''.<ref name=pmid12376792>{{Cite journal  | last1 = Tan | first1 = YM. | last2 = Wong | first2 = WK. | title = Giant Brunneroma as an unusual cause of upper gastrointestinal hemorrhage: report of a case. | journal = Surg Today | volume = 32 | issue = 10 | pages = 910-2 | month =  | year = 2002 | doi = 10.1007/s005950200179 | PMID = 12376792 }}</ref>
===General===
===General===
*Etiology:
*Benign.
**Flagellate protozoan ''Giardia lamblia''.
*Usually asymptomatic.<ref name=pmid18583897>{{Cite journal  | last1 = Lee | first1 = WC. | last2 = Yang | first2 = HW. | last3 = Lee | first3 = YJ. | last4 = Jung | first4 = SH. | last5 = Choi | first5 = GY. | last6 = Go | first6 = H. | last7 = Kim | first7 = A. | last8 = Cha | first8 = SW. | title = Brunner's gland hyperplasia: treatment of severe diffuse nodular hyperplasia mimicking a malignancy on pancreatic-duodenal area. | journal = J Korean Med Sci | volume = 23 | issue = 3 | pages = 540-3 | month = Jun | year = 2008 | doi = 10.3346/jkms.2008.23.3.540 | PMID = 18583897 }}</ref>


*Treatment
Note:
**Antibiotics, e.g. metronidazole (Flagyl).
*The AFIP uses the term ''Brunner's gland hamartoma'' for lesions > 5 mm.<ref name=pmid16928936>{{Cite journal  | last1 = Patel | first1 = ND. | last2 = Levy | first2 = AD. | last3 = Mehrotra | first3 = AK. | last4 = Sobin | first4 = LH. | title = Brunner's gland hyperplasia and hamartoma: imaging features with clinicopathologic correlation. | journal = AJR Am J Roentgenol | volume = 187 | issue = 3 | pages = 715-22 | month = Sep | year = 2006 | doi = 10.2214/AJR.05.0564 | PMID = 16928936 }}</ref>
**Multiple lesions less than 5 mm are ''hyperplasia''.
 
===Gross===
*Nodularity of the duodenum.


===Microscopic===
===Microscopic===
Features:
Features:
*+/-Loss of villi.
*Prominent Brunner's gland.
*Intraepithelial lymphocytes.  
**Tubular structures - formed by cells abundant cytoplasm that is clear with eosinophilic "cobwebs" and a round, small basal nucleus without a nucleolus.
**+Other inflammatory cells, especially PMNs, close to the luminal surface.
**Brunner's glands close to the surface epithelium - '''key feature'''.<ref name=pmid4076734>{{Cite journal  | last1 = Franzin | first1 = G. | last2 = Musola | first2 = R. | last3 = Ghidini | first3 = O. | last4 = Manfrini | first4 = C. | last5 = Fratton | first5 = A. | title = Nodular hyperplasia of Brunner's glands. | journal = Gastrointest Endosc | volume = 31 | issue = 6 | pages = 374-8 | month = Dec | year = 1985 | doi =  | PMID = 4076734 }}</ref>
*Flagellate protozoa -- '''diagnostic feature'''.
*+/-Pancreatic acini and ducts.<ref name=pmid16928936/>
**Organisms often at site of bad inflammation.
**Pale/translucent on H&E.
**Size: 12-15 micrometers (long axis) x 6-10 micrometers (short axis) -- if seen completely.<ref>[http://www.water-research.net/Giardia.htm http://www.water-research.net/Giardia.htm]</ref>
***Often look like a crescent moon ([http://en.wikipedia.org/wiki/File:Crescent_Moon.JPG image of crescent moon]) or semicircular<ref>[http://en.wikipedia.org/wiki/Semicircle http://en.wikipedia.org/wiki/Semicircle]</ref> -- as the long axis of the organism is rarely in the plane of the (histologic) section.


DDx:  
DDx:
*[[Celiac disease]] - near perfect mimic; missing giardia organisms.
*Foveolar metaplasia (isolated) - see [[peptic duodenitis]].
*[[Peptic duodenitis]].


Images:
Image:
*[[WC]]:
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2526515/figure/F3/ BGH (nih.gov)].<ref name=pmid18583897/>
**[http://commons.wikimedia.org/wiki/File:Giardiasis_duodenum_high.jpg Giardiasis - high mag. (WC)].
*[http://www.ajronline.org/content/187/3/715.full BGH (ajronline.org)].<ref name=pmid16928936/>
**[http://commons.wikimedia.org/wiki/File:Giardiasis_duodenum_low.jpg Giardiasis - low mag. (WC)].
*www:
**[http://path.upmc.edu/cases/case278.html Giardiasis - several crappy images (upmc.edu)].


==Acute duodenitis==
===Sign out===
===General===
<pre>
DDx:
DUODENUM, BIOPSY:
*Infection.
- CONSISTENT WITH BRUNNER'S GLAND HYPERPLASIA.
**Helicobactor organisms in the [[stomach]].
- SMALL BOWEL MUCOSA WITHOUT SIGNIFICANT PATHOLOGY.
*Medications (NSAIDs).
</pre>
*[[Crohn's disease]] (usually focal/patchy).
*Portal hypertension.
*[[Celiac sprue]].


===Microscopic===
<pre>
Features:
DUODENUM, BIOPSY:
*Intraepithelial lymphocytes.
- SMALL BOWEL MUCOSA WITHOUT SIGNIFICANT PATHOLOGY.
*Neutrophils - "found without searching" - '''key feature'''.
- PROMINENT BRUNNER'S GLANDS WITH EXTENSION INTO THE LAMINA PROPRIA.
*Eosinophils - "found without searching" - '''key feature'''.
</pre>
*Plasma cells (increased).


Notes:
====Superficial Brunner's glands====
*One needs stomach concurrent biopsies to r/o Helicobactor.
<pre>
*Erosions make celiac sprue much less likely.
DUODENUM, BIOPSY:
*Presence of chronic inflammation useful for NSAIDS vs. Helicobacter organisms:
- SMALL BOWEL MUCOSA WITH BRUNNER'S GLANDS THAT ARE FOCALLY SUPERFICIAL.
**NSAIDs not commonly assoc. with acute inflammation;<ref name=pmid8406146>{{cite journal |author=Taha AS, Dahill S, Nakshabendi I, Lee FD, Sturrock RD, Russell RI |title=Duodenal histology, ulceration, and Helicobacter pylori in the presence or absence of non-steroidal anti-inflammatory drugs |journal=Gut |volume=34 |issue=9 |pages=1162–6 |year=1993 |month=September |pmid=8406146 |pmc=1375446 |doi= |url=}}</ref> thus, without chronic inflammation NSAIDs are unlikely.
- NO FINDINGS SUGGESTIVE OF CELIAC DISEASE.
***Acute NSAID-related duodenitis reported.<ref name=pmid18158085>{{cite journal |author=Hashash JG, Atweh LA, Saliba T, ''et al.'' |title=Acute NSAID-related transmural duodenitis and extensive duodenal ulceration |journal=Clin Ther |volume=29 |issue=11 |pages=2448–52 |year=2007 |month=November |pmid=18158085 |doi=10.1016/j.clinthera.2007.11.012 |url=}}</ref>
- NEGATIVE FOR ACTIVE INFLAMMATION.
- NEGATIVE FOR DYSPLASIA.
</pre>


==Peptic duodenitis==
====Micro====
===General===
The sections show small bowel mucosa and a small amount of submucosa. Brunner's glands are abundant and found focally in the lamina propria.
*Due to [[peptic ulcer disease]].
**Strong association of [[Helicobacter gastritis]].


===Microscopic===
The epithelium matures appropriately.  There is no increase in intraepithelial lymphocytes.  No foveolar metaplasia of the epithelium is identified.
Features:<ref name=Ref_GLP145>{{Ref GLP|145}}</ref>
*Gastric foveolar metaplasia.
*Brunner's gland hyperplasia.
*+/-Inflammation - neutrophils. (???)
*Ulceration. (???)


DDx:
==Helicobacter duodenitis==
*[[Acute duodenitis]].
*Helicobacter is the most common cause of duodenitis.<ref>URL: [https://www.saintlukeskc.org/health-library/duodenitis https://www.saintlukeskc.org/health-library/duodenitis]. Accessed on: 2024 Feb 5.</ref><ref>URL: [https://www.webmd.com/digestive-disorders/what-is-duodenitis https://www.webmd.com/digestive-disorders/what-is-duodenitis]. Accessed on: 2024 Feb 5.</ref>
*Overall, Helicobacter is rare in the duodenum.
**Infection associated with [[Gastric heterotopia of the duodenum|gastric metaplasia]].<ref name=pmid7769188>{{cite journal |authors=Yang H, Dixon MF, Zuo J, Fong F, Zhou D, Corthésy I, Blum A |title=Helicobacter pylori infection and gastric metaplasia in the duodenum in China |journal=J Clin Gastroenterol |volume=20 |issue=2 |pages=110–2 |date=March 1995 |pmid=7769188 |doi=10.1097/00004836-199503000-00007 |url=}}</ref>


===Stains===
===Sign out===
Foveolar metaplasia:
<pre>
*[[PAS stain]] +ve.<ref name=Ref_GLP145>{{Ref GLP|145}}</ref>
A. Duodenum, Biopsy:
*[[Mucicarmine stain]] +ve.
- Active duodenitis associated with foveolar epithelium and HELICOBACTER-LIKE ORGANISMS.
- NEGATIVE for dysplasia.
</pre>


=Weird stuff=
=Weird stuff=
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==Whipple disease==
==Whipple disease==
===General===
{{Main|Whipple's disease}}
Etiology:
*Infection - caused by ''Tropheryma whipplei''.<ref>{{cite journal |author=Liang Z, La Scola B, Raoult D |title=Monoclonal antibodies to immunodominant epitope of Tropheryma whipplei |journal=Clin. Diagn. Lab. Immunol. |volume=9 |issue=1 |pages=156?9 |year=2002 |month=January |pmid=11777846 |pmc=119894 |doi= |url=http://cvi.asm.org/cgi/pmidlookup?view=long&pmid=11777846}}</ref>
 
Epidemiology:
*Very rare.
*Classically middle aged men.
 
====Clinical====
*Malabsorption (diarrhea), arthritis + others.
**Symptoms are non-specific.
 
Treatment:
*Antibiotics - for months and months.
 
===Microscopic===
Features:<ref name=pmid15476147>{{cite journal | author=Bai J, Mazure R, Vazquez H, Niveloni S, Smecuol E, Pedreira S, Mauriño E | title=Whipple's disease | journal=Clin Gastroenterol Hepatol | volume=2 | issue=10 | pages=849?60 | year=2004 | pmid=15476147  | doi=10.1016/S1542-3565(04)00387-8}}</ref>
*Infectious microorganism typically found in macrophages.
**Macrophages usually abundant - '''key feature''' that should raise Dx in DDx.
**Organisms periodic acid-Schiff (PAS) positive.
 
DDx:
*[[Mycobacterium avium complex]] (MAC).
 
Images:
*[http://commons.wikimedia.org/wiki/File:Whipple_disease_-_intermed_mag.jpg Whipple disease - intermed. mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Whipple_disease_-a-_high_mag.jpg Whipple disease - high mag. (WC)].
*[http://commons.wikimedia.org/wiki/File:Whipple2.jpg Whipple disease - poor quality - low mag. (WC)].
 
===Stains===
*PAS +ve organisms.
*AFB stain -ve -- to r/o MAI.
 
Image:
*[http://www.biomedcentral.com/content/figures/1472-6823-6-3-2-l.jpg Whipple disease - PAS stain (biomedcentral.com)].


==Microvillous inclusion disease==
==Microvillous inclusion disease==
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==Gangliocytic paraganglioma==
==Gangliocytic paraganglioma==
*Abbreviated ''GP''.
*Abbreviated ''GP''.
===General===
{{Main|Gangliocytic paraganglioma}}
*Extremely rare.<ref name=pmid22340577>{{Cite journal  | last1 = Wu | first1 = GC. | last2 = Wang | first2 = KL. | last3 = Zhang | first3 = ZT. | title = Gangliocytic paraganglioma of the duodenum: a case report. | journal = Chin Med J (Engl) | volume = 125 | issue = 2 | pages = 388-9 | month = Jan | year = 2012 | doi =  | PMID = 22340577 }}</ref>
*May be associated with [[neurofibromatosis type 1]].<ref name=pmid12754392>{{Cite journal  | last1 = Castoldi | first1 = L. | last2 = De Rai | first2 = P. | last3 = Marini | first3 = A. | last4 = Ferrero | first4 = S. | last5 = De Luca | first5 = V. | last6 = Tiberio | first6 = G. | title = Neurofibromatosis-1 and Ampullary Gangliocytic Paraganglioma Causing Biliary and Pancreatic Obstruction. | journal = Int J Gastrointest Cancer | volume = 29 | issue = 2 | pages = 93-98 | month =  | year = 2001 | doi =  | PMID = 12754392 }}</ref>
*Classified a [[neuroendocrine tumour]].<ref>URL: [http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/SmallbowelNET_11protocol.pdf http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/SmallbowelNET_11protocol.pdf]. Accessed on: 29 March 2012.</ref>
*Usually has a mix of the features seen in: [[neuroendocrine tumour]]s, [[paraganglioma]]s and [[ganglioneuroma]]s.
 
Clinical - presentation:<ref name=pmid21599949/>
*GI bleed ~ 45% of cases.
*Abdominal pain ~ 43% of cases.
*[[Anemia]] ~ 15% of cases.
 
===Gross===
*Classically in the duodenum ~90% of cases.<ref name=pmid21599949>{{Cite journal  | last1 = Okubo | first1 = Y. | last2 = Wakayama | first2 = M. | last3 = Nemoto | first3 = T. | last4 = Kitahara | first4 = K. | last5 = Nakayama | first5 = H. | last6 = Shibuya | first6 = K. | last7 = Yokose | first7 = T. | last8 = Yamada | first8 = M. | last9 = Shimodaira | first9 = K. | title = Literature survey on epidemiology and pathology of gangliocytic paraganglioma. | journal = BMC Cancer | volume = 11 | issue =  | pages = 187 | month =  | year = 2011 | doi = 10.1186/1471-2407-11-187 | PMID = 21599949 }}</ref>
 
===Microscopic===
Features - three components:<ref name=pmid15740625>{{Cite journal  | last1 = Wong | first1 = A. | last2 = Miller | first2 = AR. | last3 = Metter | first3 = J. | last4 = Thomas | first4 = CR. | title = Locally advanced duodenal gangliocytic paraganglioma treated with adjuvant radiation therapy: case report and review of the literature. | journal = World J Surg Oncol | volume = 3 | issue = 1 | pages = 15 | month = Mar | year = 2005 | doi = 10.1186/1477-7819-3-15 | PMID = 15740625 }}</ref><ref>URL: [http://surgpathcriteria.stanford.edu/gitumors/gangliocytic-paraganglioma/printable.html http://surgpathcriteria.stanford.edu/gitumors/gangliocytic-paraganglioma/printable.html]. Accessed on: 31 May 2012.</ref>
#Ganglion cells = large cells with:
#*Round large nucleus.
#*Prominent [[nucleolus]].
#*Moderate or abundant cytoplasm.
#Epithelioid cells (neuroendocrine component):
#*Arranged in nests or cords.
#*Stippled chromatin.
#Spindle cells ([[Schwannoma|schwannian]] component):
#*#Moderate or abundant cytoplasm.
#*#Nucleus spindle-shaped or ellipsoid.
 
DDx:<ref name=pmid15740625/>
*Poorly differentiated carcinoma.
*[[Neuroendocrine tumour]].
*[[Paraganglioma]].
 
Images:
*[[WC]]:
**[http://commons.wikimedia.org/wiki/File:Gangliocytic_paraganglioma_-_intermed_mag.jpg GP - intermed. mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Gangliocytic_paraganglioma_-_very_high_mag.jpg GP - very high mag. (WC)].
**[http://commons.wikimedia.org/wiki/File:Gangliocytic_paraganglioma_-_2_-_intermed_mag.jpg GP - 2 - intermed. mag. (WC)].
*www:
**[http://www.wjso.com/content/3/1/15/figure/F2 Epithelioid cells of a GP (wjso.com)].
**[http://www.wjso.com/content/3/1/15/figure/F4 Ganglion cell in a GP (wjso.com)].
**[http://www.pubcan.org/images/large/Fig_5-17_A.jpg Ganglion cells in a GP (pubcan.org)].<ref>URL: [http://www.pubcan.org/printicdotopo.php?id=5028 http://www.pubcan.org/printicdotopo.php?id=5028]. Accessed on: 15 April 2012.</ref>
**[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802175012135 GP (surgicalpathologyatlas.com)].
 
===IHC===
*Synaptophysin +ve.
*CD56 +ve.
*Chromogranin A +ve.
*HU +ve in ganglion-like cells.
*S100 +ve in spindle cells & sustentacular cells.


==Pseudomelanosis duodeni==
==Pseudomelanosis duodeni==
===General===
{{Main|Pseudomelanosis duodeni}}
*Rare.
*Consists of iron and lipofuscin.<ref name=pmid2458404>{{Cite journal  | last1 = Lin | first1 = HJ. | last2 = Tsay | first2 = SH. | last3 = Chiang | first3 = H. | last4 = Tsai | first4 = YT. | last5 = Lee | first5 = SD. | last6 = Yeh | first6 = YS. | last7 = Lo | first7 = GH. | title = Pseudomelanosis duodeni. Case report and review of literature. | journal = J Clin Gastroenterol | volume = 10 | issue = 2 | pages = 155-9 | month = Apr | year = 1988 | doi =  | PMID = 2458404 }}
</ref>
 
Associations:<ref name=pmid18253910/>
*[[Hypertension]] ~90% of cases.
*Iron supplementation ~75% of cases.
*End-stage renal disease ~60% of cases.
 
===Gross/endoscopic===
*Dark spots ~35% of cases.<ref name=pmid18253910>{{Cite journal  | last1 = Giusto | first1 = D. | last2 = Jakate | first2 = S. | title = Pseudomelanosis duodeni: associated with multiple clinical conditions and unpredictable iron stainability - a case series. | journal = Endoscopy | volume = 40 | issue = 2 | pages = 165-7 | month = Feb | year = 2008 | doi = 10.1055/s-2007-995472 | PMID = 18253910 }}</ref>
 
===Microscopic===
Features:
*Dark pigment in the lamina propria macrophages.
 
Images:
*[http://path.upmc.edu/cases/case616.html Pseudomelanosis duodeni - several images (upmc.edu)].
 
===Stains===
*Prussian blue +ve ~80% of cases.<ref name=pmid18253910/>


=Tumours=
=Tumours=
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==Adenocarcinoma of the duodenum==
==Adenocarcinoma of the duodenum==
*[[AKA]] ''duodenal adenocarcinoma''.
*[[AKA]] ''duodenal adenocarcinoma''.
 
*[[AKA]] ''duodenal carcinoma''.
===General===
{{Main|Adenocarcinoma of the duodenum}}
*Duodenum - most common site in small bowel.
 
Risk factors:
*[[Crohn's disease]].
*[[Celiac sprue]].
*[[Familial adenomatous polyposis]] (FAP).
*[[HNPCC]].
*[[Peutz-Jeghers syndrome]].
 
===Microscopic===
Features:
*Similar to large bowel adenocarcinomas - see ''[[colorectal tumours]]'' article.


==Duodenal neuroendocrine tumour==
==Duodenal neuroendocrine tumour==
{{Main|Neuroendocrine tumours}}
{{Main|Neuroendocrine tumours}}
:''Duodenal NET'' redirects here.
===General===
===General===
*Like [[neuroendocrine tumours]] elsewhere.
*Like [[neuroendocrine tumours]] elsewhere.
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*[[Adenocarcinoma of the duodenum]].
*[[Adenocarcinoma of the duodenum]].


Images:
====Images====
*[http://commons.wikimedia.org/wiki/File:Small_intestine_neuroendocrine_tumour_low_mag.jpg Neuroendocrine tumour - low mag. (WC)].
<gallery>
*[http://commons.wikimedia.org/wiki/File:Small_intestine_neuroendocrine_tumour_intermed_mag.jpg Neuroendocrine tumour - intermed. mag. (WC)].
Image:Small_intestine_neuroendocrine_tumour_low_mag.jpg | Neuroendocrine tumour - low mag. (WC)
*[http://commons.wikimedia.org/wiki/File:Small_intestine_neuroendocrine_tumour_high_mag.jpg Neuroendocrine tumour - high mag. (WC)].
Image:Small_intestine_neuroendocrine_tumour_intermed_mag.jpg | Neuroendocrine tumour - intermed. mag. (WC)
Image:Small_intestine_neuroendocrine_tumour_high_mag.jpg | Neuroendocrine tumour - high mag. (WC)
</gallery>
 
===Sign out===
<pre>
Duodenum, Biopsy:
- Incidental neuroendocrine tumour, grade 1, see comment.
- Background small bowel mucosa with Brunner's glands within normal limits.
 
Comment:
The tumour stains as follows:
POSITIVE: AE1/AE3, CD56, synaptophysin.
NEGATIVE: S-100, CD68.
PROLIFERATION (Ki-67): <2%.
</pre>


==Ampullary tumours==
==Ampullary tumours==
{{Main|Ampullary tumours}}
===General===
===General===
*Individuals with high-grade dysplasia (on biopsy) are usually treated with a pancreaticoduodenectomy (Whipple procedure), as local resections have a very high recurrence rate.<ref name=pmid16332486>{{Cite journal  | last1 = Meneghetti | first1 = AT. | last2 = Safadi | first2 = B. | last3 = Stewart | first3 = L. | last4 = Way | first4 = LW. | title = Local resection of ampullary tumors. | journal = J Gastrointest Surg | volume = 9 | issue = 9 | pages = 1300-6 | month = Dec | year = 2005 | doi = 10.1016/j.gassur.2005.08.031 | PMID = 16332486 }}</ref>
*Individuals with high-grade dysplasia (on biopsy) are usually treated with a pancreaticoduodenectomy (Whipple procedure), as local resections have a very high recurrence rate.<ref name=pmid16332486>{{Cite journal  | last1 = Meneghetti | first1 = AT. | last2 = Safadi | first2 = B. | last3 = Stewart | first3 = L. | last4 = Way | first4 = LW. | title = Local resection of ampullary tumors. | journal = J Gastrointest Surg | volume = 9 | issue = 9 | pages = 1300-6 | month = Dec | year = 2005 | doi = 10.1016/j.gassur.2005.08.031 | PMID = 16332486 }}</ref>
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===Microscopic===
===Microscopic===
Features:
Features:
*''See [[colorectal adenocarcinoma]]''.
*''See [[ampullary tumours]]''.


DDx:
DDx:
*[[Intraductal papillary mucinous tumour]] (IPMT) - a pancreatic tumour, see ''[[pancreas]]'' article.
*[[Intraductal papillary mucinous tumour]] (IPMT) - a pancreatic tumour, see ''[[pancreas]]'' article.
*[[Invasive ductal carcinoma of the pancreas]].


===Sign out===
===Sign out===
*Ampullary carcinoma - has separate staging.
*Ampullary carcinoma - has separate staging.
==Traditional adenoma==
:''Duodenal adenoma'' redirects here.
{{Main|Traditional adenoma}}
===General===
*Strong association of [[familial adenomatous polyposis]].
**In one series of 208 adenomas, almost 70% were from FAP patients.<ref name=pmid16837629/>
*Commonly found in association foveolar metaplasia - especially in sporadic cases ~60% of cases.
**In FAP ~30% of cases have foveolar metaplasia.<ref name=pmid16837629>{{Cite journal  | last1 = Rubio | first1 = CA. | title = Gastric duodenal metaplasia in duodenal adenomas. | journal = J Clin Pathol | volume = 60 | issue = 6 | pages = 661-3 | month = Jun | year = 2007 | doi = 10.1136/jcp.2006.039388 | PMID = 16837629 | PMC = 1955048}}</ref>
*A colonscopy is recommended in individuals with nonampullary duodenal adenomas, as they are likely at increased risk of large bowel adenomas.<ref name=pmid26811631>{{Cite journal  | last1 = Lim | first1 = CH. | last2 = Cho | first2 = YS. | title = Nonampullary duodenal adenoma: Current understanding of its diagnosis, pathogenesis, and clinical management. | journal = World J Gastroenterol | volume = 22 | issue = 2 | pages = 853-61 | month = Jan | year = 2016 | doi = 10.3748/wjg.v22.i2.853 | PMID = 26811631 }}</ref>
===Sign out===
<pre>
POLYP, DUODENUM, EXCISION:
- TUBULAR ADENOMA.
-- NEGATIVE FOR HIGH-GRADE DYSPLASIA.
</pre>
====Alternate====
<pre>
Polyp (Nonampullary), Duodenum, Polypectomy:
    - Tubular adenoma, NEGATIVE for high-grade dysplasia.
Comment:
A colonscopy is recommended if not done recently, as individual with nonampullary duodenal adenomas are likely at increased risk of large bowel adenomas.[1]
1. Therap Adv Gastroenterol. 2012 Mar; 5(2): 127138. doi: 10.1177/1756283X11429590
</pre>


=See also=
=See also=
Michael
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