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Difference between revisions of "Dermatologic neoplasms"
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→Less common malignant: +rare section +basosquamous carcinoma
(→Trichoblastoma: more) |
(→Less common malignant: +rare section +basosquamous carcinoma) |
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| Line 346: | Line 346: | ||
*Ki-67 high. | *Ki-67 high. | ||
*CD56 -ve. | *CD56 -ve. | ||
==Merkel cell carcinoma== | ==Merkel cell carcinoma== | ||
| Line 504: | Line 486: | ||
*[[Basal cell carcinoma]], clear cell variant. | *[[Basal cell carcinoma]], clear cell variant. | ||
*[[Trichilemmoma]]. | *[[Trichilemmoma]]. | ||
==Lymphomatoid papulosis== | |||
===General=== | |||
*Rare. | |||
*Benign behaviour. | |||
===Microscopic=== | |||
Features: | |||
*Dermal lymphocytosis. | |||
**No epidermal lymphocytes. | |||
*Focal nuclear atypia. | |||
DDx: | |||
*[[CTCL]]. | |||
*Cutaneous [[ALCL]]. | |||
===IHC=== | |||
*CD30 +ve.<ref>URL: [http://path.upmc.edu/cases/case513/dx.html http://path.upmc.edu/cases/case513/dx.html]. Accessed on: 25 January 2012.</ref> | |||
=Rare malignant= | |||
==Basosquamous carcinoma== | |||
:Should '''not''' be confused with ''basaloid [[squamous cell carcinoma]]'' ([[AKA]] ''squamous cell carcinoma, basaloid variant''. | |||
===General=== | |||
*Very rare. | |||
**Largest case series, as of 2000, 35 cases.<ref name=pmid10717618>{{Cite journal | last1 = Martin | first1 = RC. | last2 = Edwards | first2 = MJ. | last3 = Cawte | first3 = TG. | last4 = Sewell | first4 = CL. | last5 = McMasters | first5 = KM. | title = Basosquamous carcinoma: analysis of prognostic factors influencing recurrence. | journal = Cancer | volume = 88 | issue = 6 | pages = 1365-9 | month = Mar | year = 2000 | doi = | PMID = 10717618 }} | |||
</ref> | |||
*May be considered an aggressive variant of [[basal cell carcinoma]].<ref name=pmid10717618/> | |||
*Aggressive behaviour.<ref name=pmid12859383>{{Cite journal | last1 = Bowman | first1 = PH. | last2 = Ratz | first2 = JL. | last3 = Knoepp | first3 = TG. | last4 = Barnes | first4 = CJ. | last5 = Finley | first5 = EM. | title = Basosquamous carcinoma. | journal = Dermatol Surg | volume = 29 | issue = 8 | pages = 830-2; discussion 833 | month = Aug | year = 2003 | doi = | PMID = 12859383 }}.</ref> | |||
===Microscopic=== | |||
Features: | |||
*Has features of both [[basal cell carcinoma]] and [[squamous cell carcinoma of the skin|squamous cell carcinoma]].<ref name=pmid12859383/> | |||
Note: | |||
*''Busam'' notes that there is disagreement about what defines this tumour;<ref name=Ref_Derm372>{{Ref Derm|372}}</ref> however, goes on the describe it as a ''collision tumour''.<ref name=Ref_Derm397>{{Ref Derm|397}}</ref> | |||
=Intermediate= | =Intermediate= | ||