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Difference between revisions of "Bone"
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→Aneurysmal bone cyst
(→Aneurysmal bone cyst: more) |
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**May grow rapidly. | **May grow rapidly. | ||
*Osteolysis -> cystic space -> filled with blood. | *Osteolysis -> cystic space -> filled with blood. | ||
*Relatively common; in children second only to osteosarcoma.<ref>{{cite journal |author=van den Berg H, Kroon HM, Slaar A, Hogendoorn P |title=Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA" |journal=J Pediatr Orthop |volume=28 |issue=1 |pages=29–35 |year=2008 |pmid=18157043 |doi=10.1097/BPO.0b013e3181558cb5 |url=}}</ref> | *Relatively common; in children second only to [[osteosarcoma]].<ref name=pmid18157043>{{cite journal |author=van den Berg H, Kroon HM, Slaar A, Hogendoorn P |title=Incidence of biopsy-proven bone tumors in children: a report based on the Dutch pathology registration "PALGA" |journal=J Pediatr Orthop |volume=28 |issue=1 |pages=29–35 |year=2008 |pmid=18157043 |doi=10.1097/BPO.0b013e3181558cb5 |url=}}</ref> | ||
===Gross/radiologic=== | ===Gross/radiologic=== | ||
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*Air-fluid levels (radiology). | *Air-fluid levels (radiology). | ||
*Usually metaphysis of long bones, but uncommonly the femur. | *Usually metaphysis of long bones, but uncommonly the femur. | ||
*May have an "aggressive" appearance. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=emed_abc/> | Features:<ref name=emed_abc/> | ||
*Bony trabeculae ''or'' osteoid tissue. | *Bony trabeculae ''or'' osteoid tissue. | ||
*Osteoclast giant | *Osteoclast [[giant cell]]s. | ||
**Multi-nucleated giant-cells with round randomly arranged nuclei. | **Multi-nucleated giant-cells with round randomly arranged nuclei. | ||
*Benign spindle cells (fibroblasts) - surround bone/adjacent to the giant cells - '''important'''. | *Benign spindle cells (fibroblasts) - surround bone/adjacent to the giant cells - '''important'''. | ||
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DDx: | DDx: | ||
*[[Giant cell tumour of bone]] - the nuclei of the cells surrounding the giant cells are similar to those in the giant cells (round nuclei). | *[[Giant cell tumour of bone]] - the nuclei of the cells surrounding the giant cells are similar to those in the giant cells (round nuclei). | ||
* | *[[Telangiectatic osteosarcoma]]. | ||
*Other [[giant cell lesions]]. | *Other [[giant cell lesions]]. | ||