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Difference between revisions of "Inflammatory skin disorders"
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→Pyoderma gangrenosum: expand
(→Granuloma inguinale: +pyoderma gangrenosum) |
(→Pyoderma gangrenosum: expand) |
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==Pyoderma gangrenosum== | ==Pyoderma gangrenosum== | ||
===General=== | ===General=== | ||
*May be seen in [[IBD]]. | *May be seen in [[IBD]] (UC and CD) - approximately 30% of cases.<ref name=pmid16858047/> | ||
===Gross=== | |||
*Skin ulceration - classically on the legs.<ref name=pmid16858047>{{Cite journal | last1 = Brooklyn | first1 = T. | last2 = Dunnill | first2 = G. | last3 = Probert | first3 = C. | title = Diagnosis and treatment of pyoderma gangrenosum. | journal = BMJ | volume = 333 | issue = 7560 | pages = 181-4 | month = Jul | year = 2006 | doi = 10.1136/bmj.333.7560.181 | PMID = 16858047 | PMC = 1513476 | URL = http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/?tool=pubmed }}</ref> | |||
===Microscopic=== | |||
Features:<ref name=pmid16858047/> | |||
*Early: lymphocytes cells only in the dermis - often perivascular & vascular. | |||
**+/-Fibrinoid necrosis of vessels at edge of lesion. | |||
*Late: Abscess formation (neutrophils). | |||
DDx: | |||
*[[Vasculitis]]. | |||
Image: | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1513476/figure/fig5/ Pyoderma gangrenosum (nih.gov)]. | |||
=DDx for pattern= | =DDx for pattern= | ||