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{{ Infobox diagnosis | |||
| Name = {{PAGENAME}} | |||
| Image = Intranodal palisaded myofibroblastoma - very high mag.jpg | |||
| Width = 200 | |||
| Caption = IPM. [[H&E stain]]. | |||
| Micro = spindle cells with nuclear palisading, RBC extravasation | |||
| Subtypes = | |||
| LMDDx = [[schwannoma]], [[leiomyoma]] | |||
| Stains = | |||
| IHC = SMA +ve, S-100 -ve. | |||
| EM = | |||
| Molecular = | |||
| IF = | |||
| Gross = | |||
| Grossing = | |||
| Site = [[lymph node]]. | |||
| Assdx = | |||
| Syndromes = | |||
| Clinicalhx = | |||
| Signs = mass lesion | |||
| Symptoms = | |||
| Prevalence = very rare. | |||
| Bloodwork = | |||
| Rads = | |||
| Endoscopy = | |||
| Prognosis = | |||
| Other = | |||
| ClinDDx = [[lymphoma]], metastatic carcinoma. | |||
}} | |||
'''Intranodal palisaded myofibroblastoma''', abbreviated '''IPM''', is a rare tumour that classically presents as an inguinal mass.<ref name=pmid17284119>{{Cite journal | last1 = Nguyen | first1 = T. | last2 = Eltorky | first2 = MA. | title = Intranodal palisaded myofibroblastoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 2 | pages = 306-10 | month = Feb | year = 2007 | doi = 10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2 | PMID = 17284119 }}</ref> | '''Intranodal palisaded myofibroblastoma''', abbreviated '''IPM''', is a rare tumour that classically presents as an inguinal mass.<ref name=pmid17284119>{{Cite journal | last1 = Nguyen | first1 = T. | last2 = Eltorky | first2 = MA. | title = Intranodal palisaded myofibroblastoma. | journal = Arch Pathol Lab Med | volume = 131 | issue = 2 | pages = 306-10 | month = Feb | year = 2007 | doi = 10.1043/1543-2165(2007)131[306:IPM]2.0.CO;2 | PMID = 17284119 }}</ref> | ||
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#Intracellular and extracellular fuchsinophilic bodies. | #Intracellular and extracellular fuchsinophilic bodies. | ||
#*Smooth muscle actin +ve. | #*Smooth muscle actin +ve. | ||
Notes: | Notes: | ||
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**Image: [http://www.flickr.com/photos/53376324@N08/5387821397/in/photostream Fuchsinophilic material (flickr.com)] - red. | **Image: [http://www.flickr.com/photos/53376324@N08/5387821397/in/photostream Fuchsinophilic material (flickr.com)] - red. | ||
Images: | DDx:<ref>{{Cite journal | last1 = Sarma | first1 = NH. | last2 = Arora | first2 = KS. | last3 = Varalaxmi | first3 = KP. | title = Intranodal palisaded myofibroblastoma: a case report and an update on etiopathogenesis and differential diagnosis. | journal = J Cancer Res Ther | volume = 9 | issue = 2 | pages = 295-8 | month = | year = | doi = 10.4103/0973-1482.113395 | PMID = 23771380 }}</ref> | ||
*[[Schwannoma]]. | |||
*[[Leiomyoma]]. | |||
*[[Leiomyosarcoma]]. | |||
*[[Malignant melanoma]]. | |||
*[[Kaposi sarcoma]]. | |||
*Metastatic carcinoma. | |||
===Images=== | |||
<gallery> | |||
Image: Intranodal palisaded myofibroblastoma - low mag.jpg | IPM - low mag. (WC/Nephron) | |||
Image: Intranodal palisaded myofibroblastoma - intermed mag.jpg | IPM - intermed. mag. (WC/Nephron) | |||
Image: Intranodal palisaded myofibroblastoma - high mag.jpg | IPM - high mag. (WC/Nephron) | |||
Image: Intranodal palisaded myofibroblastoma - very high mag.jpg | IPM - very high mag. (WC/Nephron) | |||
Image: Intra-nodal palisaded myofibroblastoma.jpg | IPM - high mag. (WC) | |||
</gallery> | |||
www: | |||
*[http://www.surgicalpathologyatlas.com/glfusion/mediagallery/media.php?f=0&sort=0&s=20080802163636511 IPM (surgicalpathologyatlas.com)]. | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC496726/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid1918406>{{Cite journal | last1 = Bigotti | first1 = G. | last2 = Coli | first2 = A. | last3 = Mottolese | first3 = M. | last4 = Di Filippo | first4 = F. | title = Selective location of palisaded myofibroblastoma with amianthoid fibres. | journal = J Clin Pathol | volume = 44 | issue = 9 | pages = 761-4 | month = Sep | year = 1991 | doi = | PMID = 1918406 }}</ref> | |||
*[http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3146916/figure/F4/ Amianthoid fibers (nih.gov)].<ref name=pmid21718465/> | |||
*[http://path.upmc.edu/cases/case121/micro.html IPM - several images (upmc.edu)]. | |||
==IHC== | ==IHC== | ||
*SMA +ve. | *SMA +ve. | ||
*Cyclin D1 +ve. | *Vimentin +ve. | ||
*Cyclin D1 +ve/-ve.<ref name=pmid23771380>{{Cite journal | last1 = Sarma | first1 = NH. | last2 = Arora | first2 = KS. | last3 = Varalaxmi | first3 = KP. | title = Intranodal palisaded myofibroblastoma: a case report and an update on etiopathogenesis and differential diagnosis. | journal = J Cancer Res Ther | volume = 9 | issue = 2 | pages = 295-8 | month = | year = | doi = 10.4103/0973-1482.113395 | PMID = 23771380 }}</ref> | |||
Other: | Other: | ||
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*Desmin -ve | *Desmin -ve | ||
*Ki-67 - low. | *Ki-67 - low. | ||
*HMB-45 -ve. | |||
==See also== | ==See also== |
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