Difference between revisions of "Pulmonary cytopathology"

Pulmonary cytopathology (view source)

96 bytes added , 12:15, 12 April 2012

→‎Squamous cell carcinoma: re-arr to well-diff and poorly diff

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 {{Main|Squamous cell carcinoma}}
-===Microscopic===
+===Cytology===
-*Mix of spindle cells/epithelioid cells, present in clusters, +/-small number of single cells.
+General - features:
-*Keratinization:
+*Nuclear features of malignancy (required):
-**Orange/red staining on Pap stain.
-***Poorly differentiated SCC = not orange/red.
-**"Intense" (blue) staining of cells on rapid Romanowsky + pyknotic (small shriveled) nucleus.<ref>GS. 24 February 2010.</ref>
-*"Dense" appearing cytoplasm.
-**+/-Laminae (layers)/lines in the cytoplasm.
-*Nuclear features of malignancy (required for diagnosis):
 **Irregular nuclear membrane, e.g. notches, sharp discontinuities.
 **Nuclear hyperchromasia - "jet-black" nuclei on Pap stain '''key feature'''.
 **Increased [[NC ratio]].
 **Variation of nuclear size from cell-to-cell.
+Features - well-differentiated:
+*Classically single cells.
+*Keratinized = orange/red staining on Pap stain.
+**"Intense" (blue) staining of cells on rapid Romanowsky + pyknotic (small shriveled) nucleus.<ref>GS. 24 February 2010.</ref>
+Features - poorly differentiated:
+*Mix of spindle cells/epithelioid cells usu. present in clusters '''without''' a common border.
+*Usu. lack keratinization, i.e. not orange/red.
+*"Dense" appearing cytoplasm.
+**+/-Laminae (layers)/lines in the cytoplasm.
 Image(s):