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Difference between revisions of "Endometrial carcinoma"
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==Grading (FIGO)== | ==Grading (FIGO)== | ||
Based on gland formation & adjusted by nuclear pleomorphism:<ref>{{Ref PBoD|1087-8}}</ref><ref>URL: [http://www.pathologyoutlines.com/uterus.html#endometrialcarc http://www.pathologyoutlines.com/uterus.html#endometrialcarc].</ref><ref>URL: [http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm].</ref><ref name=pmid12496701>{{cite journal |author=Ayhan A, Taskiran C, Yuce K, Kucukali T |title=The prognostic value of nuclear grading and the revised FIGO grading of endometrial adenocarcinoma |journal=Int. J. Gynecol. Pathol. |volume=22 |issue=1 |pages=71–4 |year=2003 |month=January |pmid=12496701 |doi= |url=}}</ref> | |||
*Grade 1: <5% solid component. | |||
*Grade 2: 5-50% solid component. | |||
*Grade 3: >50% solid component. | |||
Modifiers/adjustment: | Modifiers/adjustment: | ||
*High grade nuclei upgrades cancer by one; high grade nuclei = increased size, irregular large nucleoli, irregular chromatin pattern (clumped, coarse).<ref>{{Ref DCHH|240}}</ref> | *High grade nuclei upgrades cancer by one; high grade nuclei = increased size, irregular large nucleoli, irregular chromatin pattern (clumped, coarse).<ref>{{Ref DCHH|240}}</ref> | ||
Notes: | Notes: | ||
*Officially only sanctioned for ''[[endometrioid endometrial carcinoma]]''. | *Officially only sanctioned for ''[[endometrioid endometrial carcinoma]]''. | ||
**May be used for [[mucinous endometrial carcinoma]]. | |||
**Papillary serous carcinoma and clear cell carcinomas are ''not'' assigned a grade ''or'' grade 3 by definition. | |||
==Staging== | ==Staging== | ||