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Other renal tumours (not covered in this article): | Other renal tumours (not covered in this article): | ||
*Postneuroblastoma RCC. | *Postneuroblastoma RCC. | ||
*Neuroblastoma. | *[[Neuroblastoma]]. | ||
*[[PNET]]. | *[[PNET]]. | ||
*[[Synovial sarcoma]]. | *[[Synovial sarcoma]]. | ||
*[[Lymphoma]]. | *[[Lymphoma]]. | ||
The | The [[Kidney_tumours#Renal_translocation_carcinomas|renal translocation carcinomas]] are covered in: | ||
*[[Renal tumour with Xp11.2 translocation]]. | |||
*[[Renal tumour with t(6;11) translocation]]. | |||
=Specific tumours= | =Specific tumours= | ||
==Wilms tumour== | ==Wilms tumour== | ||
*[[AKA]] nephroblastoma, AKA Wilms' tumour. | *[[AKA]] nephroblastoma, AKA Wilms' tumour. | ||
{{Main|Wilms tumour}} | |||
==Metanephric stromal tumour== | ==Metanephric stromal tumour== | ||
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====Cellular==== | ====Cellular==== | ||
Features:<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | Features:<ref name=Ref_WMSP284>{{Ref WMSP|284}}</ref> | ||
*Plump cells with vesicular nuclei. | *Plump cells with [[vesicular nuclei]]. | ||
*Well-defined border. | *Well-defined border. | ||
*Mitotically active. | *Mitotically active. | ||
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===Molecular=== | ===Molecular=== | ||
Cellular mesoblastic nephroma: | Cellular mesoblastic nephroma:<ref name=pmid29683818>{{Cite journal | last1 = Rudzinski | first1 = ER. | last2 = Lockwood | first2 = CM. | last3 = Stohr | first3 = BA. | last4 = Vargas | first4 = SO. | last5 = Sheridan | first5 = R. | last6 = Black | first6 = JO. | last7 = Rajaram | first7 = V. | last8 = Laetsch | first8 = TW. | last9 = Davis | first9 = JL. | title = Pan-Trk Immunohistochemistry Identifies NTRK Rearrangements in Pediatric Mesenchymal Tumors. | journal = Am J Surg Pathol | volume = 42 | issue = 7 | pages = 927-935 | month = Jul | year = 2018 | doi = 10.1097/PAS.0000000000001062 | PMID = 29683818 }}</ref> | ||
*t(12:15)(p13;q25) ETV6/NTRK3. | *t(12:15)(p13;q25) ETV6/[[NTRK3]]. | ||
**Same [[translocation]] if found in ''[[infantile fibrosarcoma]]''. | **Same [[translocation]] if found in ''[[infantile fibrosarcoma]]''. | ||
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*Renal medulla. | *Renal medulla. | ||
*+/-Cystic. | *+/-Cystic. | ||
Image: | |||
*[http://www.flickr.com/photos/35441329@N05/4171714950/in/photostream/ CCS of the kidney (flickr.com)]. | |||
*[http://www.flickr.com/photos/35441329@N05/4171714940/in/photostream/ CCS of the kidney (flickr.com)]. | |||
===Microscopic=== | ===Microscopic=== | ||
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Images: | Images: | ||
*[http://path.upmc.edu/cases/case201.html Clear cell sarcoma of the kidney - several images (upmc.edu)]. | *[http://path.upmc.edu/cases/case201.html Clear cell sarcoma of the kidney - several images (upmc.edu)]. | ||
===IHC=== | |||
Features:<ref name=pmid17883043>{{Cite journal | last1 = Viswanathan | first1 = S. | last2 = Dave | first2 = BK. | last3 = Desai | first3 = SB. | title = Clear cell sarcoma of the kidney--a study of seven cases over a period of three years. | journal = Indian J Pathol Microbiol | volume = 50 | issue = 2 | pages = 270-3 | month = Apr | year = 2007 | doi = | PMID = 17883043 }}</ref> | |||
*Vimentin +ve. | |||
*Desmin -ve. | |||
*Smooth muscle actin -ve. | |||
*NSE -ve. | |||
*S-100 -ve. | |||
===Molecular=== | |||
*t(10;17)(q22;p13) - reported in 6 of 50 cases.<ref name=pmid22294382>{{Cite journal | last1 = O'Meara | first1 = E. | last2 = Stack | first2 = D. | last3 = Lee | first3 = CH. | last4 = Garvin | first4 = AJ. | last5 = Morris | first5 = T. | last6 = Argani | first6 = P. | last7 = Han | first7 = JS. | last8 = Karlsson | first8 = J. | last9 = Gisselson | first9 = D. | title = Characterization of the chromosomal translocation t(10;17)(q22;p13) in clear cell sarcoma of kidney. | journal = J Pathol | volume = 227 | issue = 1 | pages = 72-80 | month = May | year = 2012 | doi = 10.1002/path.3985 | PMID = 22294382 }}</ref> | |||
==Renal rhabdoid tumour== | ==Renal rhabdoid tumour== | ||
*[[AKA]] ''rhabdoid tumour of the kidney'', abbreviated ''RTK''. | *[[AKA]] ''rhabdoid tumour of the kidney'', abbreviated ''RTK''. | ||
{{Main|Renal rhabdoid tumour}} | |||
==Renal cell carcinoma== | ==Renal cell carcinoma== | ||
===General=== | ===General=== | ||
*Similar to in adults. | *Similar to in adults. | ||
*Clear cell RCC not common - a tumour with the clear cell histomorphology is more often a ''renal tumour with | *[[Clear cell renal cell carcinoma|Clear cell RCC]] not common - a tumour with the clear cell histomorphology is more often a ''[[renal tumour with Xp11.2 translocation]]''. | ||
====Papillary RCC==== | ====Papillary RCC==== |
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