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Difference between revisions of "Stomach"
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→Helicobacter gastritis
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==Helicobacter gastritis== | ==Helicobacter gastritis== | ||
===General=== | ===General=== | ||
*Several Helicobacter species can cause gastritis | *Several Helicobacter species can cause gastritis: | ||
**''Helicobacter pylori'' - most common. | |||
**''Helicobacter heilmannii''. | |||
=== | Epidemiologic associations: | ||
Helicobacter infections are associated with:<ref>{{Ref PBoD|814}}</ref> | |||
*Gastritis. | |||
*Peptic ulcers. | |||
*Cancer. | |||
**Carcinoma. | |||
**[[MALT lymphoma]]. | |||
===Microscopic=== | |||
Features: | |||
*Small - smaller than the nucleus of the gastric foveolar cell. | *Small - smaller than the nucleus of the gastric foveolar cell. | ||
**On 400x they are still possible to miss. | **On 400x they are still possible to miss. | ||
*Look close to the opening of the gastric glands. | *Look close to the opening of the gastric glands. | ||
*Are often are found in groups. | *Are often are found in groups. | ||
*Location - can be antrum and/or body.<ref>{{cite journal |author=Maaroos HI, Kekki M, Villako K, Sipponen P, Tamm A, Sadeniemi L |title=The occurrence and extent of Helicobacter pylori colonization and antral and body gastritis profiles in an Estonian population sample |journal=Scand. J. Gastroenterol. |volume=25 |issue=10 |pages=1010-7 |year=1990 |month=October |pmid=2263873 |doi= |url=}}</ref> | *Location - can be antrum and/or body.<ref>{{cite journal |author=Maaroos HI, Kekki M, Villako K, Sipponen P, Tamm A, Sadeniemi L |title=The occurrence and extent of Helicobacter pylori colonization and antral and body gastritis profiles in an Estonian population sample |journal=Scand. J. Gastroenterol. |volume=25 |issue=10 |pages=1010-7 |year=1990 |month=October |pmid=2263873 |doi= |url=}}</ref> | ||
*Helicobacter don't like the intestinal mucosa or mucosa that has undergone intestinal metaplasia -- you're unlikely to find 'em there. | *Helicobacter don't like the intestinal mucosa or mucosa that has undergone intestinal metaplasia -- you're unlikely to find 'em there. | ||
*''Helicobacter pylori'': | |||
**Typically have a "v" shape ''or'' a comma-like shape. | |||
*''Helicobacter heilmannii'': | |||
**Corkscrew appearance. | |||
Images: | Images: | ||
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*[http://commons.wikimedia.org/wiki/Category:Helicobacter_gastritis Set of images - HP gastritis (WC)]. | *[http://commons.wikimedia.org/wiki/Category:Helicobacter_gastritis Set of images - HP gastritis (WC)]. | ||
=== | ===Stains=== | ||
*[[Cresyl violet stain]] - background and organisms blue. | |||
* | *[[Warthin-Starry stain]] - background yellow, organisms black. | ||
* | |||
===IHC=== | |||
*Helicobacter pylori IHC stain +ve. | |||
* | |||
==Intestinal metaplasia== | ==Intestinal metaplasia== | ||