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Difference between revisions of "Lymph nodes"
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WFH4
m (→LN follicles) |
(WFH4) |
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==LN architecture== | ==LN architecture== | ||
Lymph node architecture (superficial to deep):<ref> | Lymph node architecture (superficial to deep):<ref name=Ref_WFH4_206-8>{{Ref WFH4|206-8}}</ref> | ||
*Capsule. | *Capsule. | ||
*Subcapsular sinus. | *Subcapsular sinus. | ||
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==LN follicles== | ==LN follicles== | ||
Types of follicles:<ref> | Types of follicles:<ref name=Ref_WFH4_208>{{Ref WFH4|208}}</ref> | ||
#Primary follicle - no germinal center (pale area). | #Primary follicle - no germinal center (pale area). | ||
#Secondary follicle - have a ''germinal center'' (pale area) and ''mantle zone'' (rim of darker staining lymphocytes). | #Secondary follicle - have a ''germinal center'' (pale area) and ''mantle zone'' (rim of darker staining lymphocytes). | ||
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==Location and cell types== | ==Location and cell types== | ||
Germinal centers:<ref> | Germinal centers:<ref name=Ref_WFH4_210>{{Ref WFH4|210}}</ref> | ||
*Site of B lymphocyte proliferation; ''follicle center cells''. | *Site of B lymphocyte proliferation; ''follicle center cells''. | ||
**Centroblasts - usually superficial aspect. | **Centroblasts - usually superficial aspect. | ||
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*''Follicular dendritic cells''. | *''Follicular dendritic cells''. | ||
Paracortex:<ref> | Paracortex:<ref name=Ref_WFH4_211>{{Ref WFH4|211}}</ref> | ||
*Site of T lymphocytes. | *Site of T lymphocytes. | ||
*''Interdigitating dendritic cell''. | *''Interdigitating dendritic cell''. | ||
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==B cell cycle== | ==B cell cycle== | ||
B cell cycle/maturation:<ref> | B cell cycle/maturation:<ref name=Ref_WFH4_210>{{Ref WFH4|210}}</ref> | ||
#Centroblast (CB): | #Centroblast (CB): | ||
#*Appearance:<ref>URL: [http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm]. Accessed on: 31 January 2010.</ref> | #*Appearance:<ref>URL: [http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm http://www.healthsystem.virginia.edu/internet/hematology/HessEDD/BenignHematologicDisorders/normal-hematopoietic-cells/Secondary-lymphoid-organs-and-tissues.cfm]. Accessed on: 31 January 2010.</ref> | ||