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Difference between revisions of "Neuropathology tumours"
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→Choroid plexus carcinoma: more tweak
(→Microscopic: more) |
(→Choroid plexus carcinoma: more tweak) |
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==Choroid plexus carcinoma== | ==Choroid plexus carcinoma== | ||
===General=== | ===General=== | ||
* | *Usually pediatric population. | ||
*Malignant counterpart of ''[[choroid plexus papilloma]]''.<ref name=pmid19679976>{{Cite journal | last1 = Singh | first1 = A. | last2 = Vermani | first2 = S. | last3 = Shruti | first3 = S. | title = Choroid plexus carcinoma: report of two cases. | journal = Indian J Pathol Microbiol | volume = 52 | issue = 3 | pages = 405-7 | month = | year = | doi = 10.4103/0377-4929.55009 | PMID = 19679976 }}</ref> | *Malignant counterpart of ''[[choroid plexus papilloma]]''.<ref name=pmid19679976>{{Cite journal | last1 = Singh | first1 = A. | last2 = Vermani | first2 = S. | last3 = Shruti | first3 = S. | title = Choroid plexus carcinoma: report of two cases. | journal = Indian J Pathol Microbiol | volume = 52 | issue = 3 | pages = 405-7 | month = | year = | doi = 10.4103/0377-4929.55009 | PMID = 19679976 }}</ref> | ||
*Poor prognosis - WHO grade III.<ref name=pmid20644273>{{Cite journal | last1 = Menon | first1 = G. | last2 = Nair | first2 = SN. | last3 = Baldawa | first3 = SS. | last4 = Rao | first4 = RB. | last5 = Krishnakumar | first5 = KP. | last6 = Gopalakrishnan | first6 = CV. | title = Choroid plexus tumors: an institutional series of 25 patients. | journal = Neurol India | volume = 58 | issue = 3 | pages = 429-35 | month = | year = | doi = 10.4103/0028-3886.66455 | PMID = 20644273 |URL = http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref> | *Poor prognosis - WHO grade III.<ref name=pmid20644273>{{Cite journal | last1 = Menon | first1 = G. | last2 = Nair | first2 = SN. | last3 = Baldawa | first3 = SS. | last4 = Rao | first4 = RB. | last5 = Krishnakumar | first5 = KP. | last6 = Gopalakrishnan | first6 = CV. | title = Choroid plexus tumors: an institutional series of 25 patients. | journal = Neurol India | volume = 58 | issue = 3 | pages = 429-35 | month = | year = | doi = 10.4103/0028-3886.66455 | PMID = 20644273 |URL = http://www.neurologyindia.com/article.asp?issn=0028-3886;year=2010;volume=58;issue=3;spage=429;epage=435;aulast=Menon }}</ref> | ||
*Classically posterior fossa. | *Classically posterior fossa. | ||
*Intraventricular mass. | |||
===Microscopic=== | ===Microscopic=== | ||
Features:<ref name=pmid19679976/> | Features:<ref name=pmid19679976/> | ||
*Choroid plexus epithelium with [[nuclear pleomorphism]] & high NC ratio. | *Choroid plexus epithelium with [[nuclear pleomorphism]] & high [[NC ratio]]. | ||
*Mitoses. | *Mitoses. | ||
*Necrosis. | *Necrosis. | ||
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*Atypical plexus papilloma - has features intermediate between ''choroid plexus papilloma'' and ''choroid plexus carcinoma''.<ref name=pmid20644273/> | *Atypical plexus papilloma - has features intermediate between ''choroid plexus papilloma'' and ''choroid plexus carcinoma''.<ref name=pmid20644273/> | ||
*[[Atypical teratoid/rhabdoid tumour]]. | *[[Atypical teratoid/rhabdoid tumour]]. | ||
Images: | |||
*[http://path.upmc.edu/cases/case198/micro.html Choroid plexus carcinoma - several images (upmc.edu)]. | |||
===IHC=== | ===IHC=== | ||