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Difference between revisions of "Malignant melanoma"
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→Microscopic: tweak form
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**Loosely cohesive; mix of small nests of cells, single cells. | **Loosely cohesive; mix of small nests of cells, single cells. | ||
***Nests often have clefting with surrounding tissue. | ***Nests often have clefting with surrounding tissue. | ||
** | **Mix of spindle cells and epithelioid cells: | ||
**+/-Occasional large binucleated cells. | ***+/-Occasional large binucleated cells. | ||
**Cytoplasm | ***Cytoplasm with brown pigment (melanin). | ||
**Prominent (large) red nucleoli (like in ''serous carcinoma'' of the ovary). | ***Prominent (large) red nucleoli (like in ''serous carcinoma'' of the ovary). | ||
**Marked nuclear pleomorphism - variation in cell size, shape & staining (like in ''serous carcinoma'' of the ovary). | ***Marked nuclear pleomorphism - variation in cell size, shape & staining (like in ''serous carcinoma'' of the ovary). | ||
**[[Nuclear pseudoinclusions]] (like in ''papillary thyroid carcinoma''). | ***[[Nuclear pseudoinclusions]] (like in ''papillary thyroid carcinoma''). | ||
Notes: | Notes: | ||