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Difference between revisions of "Endometrial carcinoma"
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===Management=== | ===Management=== | ||
"Hysterectomy" is the | "Hysterectomy" is the standard treatment for endometrial carcinoma. | ||
**In low-grade carcinomas (i.e. low grade endometrioid type), if the woman isn't done with their childbearing, the treatment may be hormones and surveillance biopsies.<ref name=pmid19758691>{{cite journal |author=Zivanovic O, Carter J, Kauff ND, Barakat RR |title=A review of the challenges faced in the conservative treatment of young women with endometrial carcinoma and risk of ovarian cancer |journal=Gynecol. Oncol. |volume=115 |issue=3 |pages=504–9 |year=2009 |month=December |pmid=19758691 |doi=10.1016/j.ygyno.2009.08.011 |url=}}</ref> | |||
Details: | Details: | ||
*Low grade and low stage endometrioid carcinoma: ''total hysterectomy'' (includes cervix). | *Low grade and low stage endometrioid carcinoma: ''total hysterectomy'' (includes cervix). | ||
*Non-endometrioid or high stage or grade endometrioid: ''radical hysterectomy'' (includes cervix, vaginal cuff, parametrial tissue). | *Non-endometrioid ''or'' high stage endometrioid ''or'' high-grade endometrioid: ''radical hysterectomy'' (includes cervix, vaginal cuff, parametrial tissue). | ||
==Subtypes== | ==Subtypes== | ||
#Endometrioid - '''most common''', patient typically is 55-65 years old and obese. | |||
#Serous - patients classically older than endometrioid subtype, arise in atrophic endometrium. | |||
#Clear cell. | |||
===Microscopic (summary)=== | |||
Features in most common subtypes (in short): | |||
*Serous: | *Serous: | ||
**Columnar cells | **Columnar cells. | ||
**Cilia | **Cilia. | ||
**Psammoma bodies | **Psammoma bodies. | ||
**Papillae. | **Papillae. | ||
*Endometrioid: | *Endometrioid: | ||
| Line 39: | Line 39: | ||
*Clear cell. | *Clear cell. | ||
**Classically clear cells... but not always. | **Classically clear cells... but not always. | ||
**Hobnailing (apical cytoplasm > cytoplasm on basement membrane). | **Hobnailing (apical cytoplasm > cytoplasm on basement membrane). | ||
Notes: | Notes: | ||
| Line 69: | Line 69: | ||
**IVb = distant mets (intraabdominal, inguinal nodes). | **IVb = distant mets (intraabdominal, inguinal nodes). | ||
Ref: <ref>{{Ref PBoD|1088}}</ref>, <ref>[http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm]</ref> | Ref: <ref>{{Ref PBoD|1088}}</ref>, <ref>[http://www.emedicine.com/med/topic2832.htm http://www.emedicine.com/med/topic2832.htm]</ref> | ||
<ref>[http://www.cancerfacts.com/GeneralContent/Uterine/Gen_Diagnosis.asp?CB=11 | <ref>[http://www.cancerfacts.com/GeneralContent/Uterine/Gen_Diagnosis.asp?CB=11 Staging with groovy graphics (cancerfacts.com)]</ref> | ||
==See also== | ==See also== | ||