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Difference between revisions of "Heart"
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→Chagas disease: more
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(→Chagas disease: more) |
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===General=== | ===General=== | ||
* | *Essentially a South American disease. | ||
*Etiology: protozoa ''Trypanosoma cruzi'' - transmitted by ''reduvid bugs'',<ref name=PMH0002348>URL: [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002348/ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002348/]. Accessed on: 4 December 2011.</ref> also known as ''kissing bug''.<ref>URL: [http://www.who.int/topics/chagas_disease/en/ http://www.who.int/topics/chagas_disease/en/]. Accessed on: 1 December 2011.</ref> | *Etiology: protozoa ''Trypanosoma cruzi'' - transmitted by ''reduvid bugs'',<ref name=PMH0002348>URL: [http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002348/ http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0002348/]. Accessed on: 4 December 2011.</ref> also known as ''kissing bug''.<ref>URL: [http://www.who.int/topics/chagas_disease/en/ http://www.who.int/topics/chagas_disease/en/]. Accessed on: 1 December 2011.</ref> | ||
Clinical:<ref name=pmid17072450>{{Cite journal | last1 = Teixeira | first1 = AR. | last2 = Nascimento | first2 = RJ. | last3 = Sturm | first3 = NR. | title = Evolution and pathology in chagas disease--a review. | journal = Mem Inst Oswaldo Cruz | volume = 101 | issue = 5 | pages = 463-91 | month = Aug | year = 2006 | doi = | PMID = 17072450 |URL = http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762006000500001&lng=en&nrm=iso&tlng=en }}</ref> | |||
*Depends on phase of infection. | |||
*Arrhythmias (late). | |||
Dx:<ref>URL: [http://www.cdc.gov/parasites/chagas/diagnosis.html http://www.cdc.gov/parasites/chagas/diagnosis.html]. Accessed on: 4 December 2011.</ref> | Dx:<ref>URL: [http://www.cdc.gov/parasites/chagas/diagnosis.html http://www.cdc.gov/parasites/chagas/diagnosis.html]. Accessed on: 4 December 2011.</ref> | ||
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===Microscopic=== | ===Microscopic=== | ||
Features: | Features: | ||
*Inflammation - main finding.<ref name=pmid17072450/> | |||
*Intracellular organisms. | *Intracellular organisms. | ||
*Neuronal loss in atrial ganglia.<ref name=pmid17339569/> | |||
Image: | Image: | ||
*[http://www.uaz.edu.mx/histo/pathology/ed/ch_9c/c9c_chagas.htm Chagas disease (uaz.edu.mx)]. | *[http://www.uaz.edu.mx/histo/pathology/ed/ch_9c/c9c_chagas.htm Chagas disease (uaz.edu.mx)]. | ||
===IHC=== | |||
*Anti–T cruzi immunoperoxidase.<ref name=pmid17339569>{{Cite journal | last1 = Marin-Neto | first1 = JA. | last2 = Cunha-Neto | first2 = E. | last3 = Maciel | first3 = BC. | last4 = Simões | first4 = MV. | title = Pathogenesis of chronic Chagas heart disease. | journal = Circulation | volume = 115 | issue = 9 | pages = 1109-23 | month = Mar | year = 2007 | doi = 10.1161/CIRCULATIONAHA.106.624296 | PMID = 17339569 |URL = http://circ.ahajournals.org/content/115/9/1109.long }}</ref> | |||
==Cardiac amyloidosis== | ==Cardiac amyloidosis== | ||