Nasopharyngeal angiofibroma

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Nasopharyngeal angiofibroma is a benign lesion of the head and neck.

Nasopharyngeal angiofibroma
Diagnosis in short

Nasopharyngeal angiofibroma. H&E stain.
LM fibroblastic cells with plump (near cuboidal) nuclei, fibrous stroma, abundant capillaries
Site head and neck - nasopharynx
Clinical history male, adolescents young to adults, frequent nose bleeds
Prevalence uncommon
Prognosis benign
Treatment surgical resection

General

  • Classically adolescent males with recurrent nose bleeds.
    • Age range 8-41 in one series of 162 cases.[1]
  • Can be subtyped by location into three groups.[2]

Microscopic

Features:[3]

  • Fibroblastic cells with plump (near cuboidal) nuclei.
  • Fibrous stroma.
  • Abundant capillaries.

Images

  • Intermed. mag.

  • High mag.

  • Very high mag.

  • High mag.

See also

References

  1. ↑ Huang, Y.; Liu, Z.; Wang, J.; Sun, X.; Yang, L.; Wang, D. (Aug 2014). "Surgical management of juvenile nasopharyngeal angiofibroma: analysis of 162 cases from 1995 to 2012.". Laryngoscope 124 (8): 1942-6. doi:10.1002/lary.24522. PMID 24222212.
  2. ↑ Yi, Z.; Fang, Z.; Lin, G.; Lin, C.; Xiao, W.; Li, Z.; Cheng, J.; Zhou, A.. "Nasopharyngeal angiofibroma: a concise classification system and appropriate treatment options.". Am J Otolaryngol 34 (2): 133-41. doi:10.1016/j.amjoto.2012.10.004. PMID 23332298.
  3. ↑ Klatt, Edward C. (2006). Robbins and Cotran Atlas of Pathology (1st ed.). Saunders. pp. 144. ISBN 978-1416002741.
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