Female adnexal tumour of probable Wolffian origin
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Female adnexal tumour of probable Wolffian origin, abbreviated FATWO, is a rare usually benign tumour.
| Female adnexal tumour of probable Wolffian origin | |
|---|---|
| Diagnosis in short | |
 FATWO. H&E stain. | |
| IHC | vimentin +ve, AE1/AE3 +ve, CAM5.2 +ve, AR +ve (~80% of cases) |
| Site | adnexa (ovary) |
|
| |
| Prevalence | very rare |
| Prognosis | usu. benign |
It is also known as Wolffian adnexal tumour, abbreviated WAT.
General
Gross
Adnexal location - as the name suggests:[3]
- Broad ligament of ovary.
- Mesosalpinx.
- Ovarian hilus - less common.
Microscopic
Features:[3]
- Variable architecture:
- Tubular or glandular.
- Solid - spindle cells.
- Multicystic.
DDx:
Images
FATWO - intermed. mag.
FATWO - high mag.
FATWO - very high mag.
IHC
Features:[3]
- Vimentin +ve.
- AE1/AE3 +ve.
- CAM5.2 +ve.
- CK7 +ve -- focal, sometimes -ve.
- AR +ve ~80% of cases.
- Inhibin +ve ~70% of cases.
Others:[3]
- CK20 -ve.
- mCEA -ve.
See also
References
- ↑ Tianmin, X.; Weiqim, C.; Mianhua, C.; Xiaocui, L.; Hongwen, G.; Min, Y. (2012). "Tumor of the mesosalpinx: case report of a female adnexal tumor of probable Wolffian origin.". Eur J Gynaecol Oncol 33 (2): 233-5. PMID 22611973.
- ↑ Heller, DS.; Kadire, B.; Cracchiolo, B.. "Malignant female adnexal tumor of probable Wolffian origin: a case report.". J Reprod Med 56 (3-4): 175-7. PMID 21542539.
- ↑ 3.0 3.1 3.2 3.3 Devouassoux-Shisheboran, M.; Silver, SA.; Tavassoli, FA. (Jul 1999). "Wolffian adnexal tumor, so-called female adnexal tumor of probable Wolffian origin (FATWO): immunohistochemical evidence in support of a Wolffian origin.". Hum Pathol 30 (7): 856-63. PMID 10414506.