Chronic granulomatous disease

Chronic granulomatous disease, abbreviated CGD, is a specific diagnosis; it should not be understood as a granulomatous disease that is of a long duration.

CGD is disorder of neutrophils, and typically leads to widespread granulomas.

General

• Five different genetic defects have been identified that cause the disease.
• Individual with the condition have an increased susceptibility to infections.
• Usually presents in infancy or childhood.
• Incidence estimated at 1/200,000-1/250,000.

Microscopic

Features:

• Granulomas - see Basics.

DDx:

• Crohn's disease - essentially indistinguishable histomorphologically in the GI tract.