Prostatic specific acid phosphatase
Prostatic specific acid phosphatase, abbreviated PSAP, is prostate marker that predated prostate-specific antigen (PSA).
It is also known as prostatic acid phosphatase, abbreviated PAP.
General
- Cannot differentiate between benign prostate and prostate cancer, like PSA.[1]
Positive
- Benign prostate.
- Prostate cancer.
- Some hindgut neuroendocrine tumours.[2][3]
Microscopic
Features:
- Cytoplasmic staining.
Images
PSAP - intermed. mag.
PSAP - high mag.
References
- ↑ Sauvageot, J.; Epstein, JI. (Jan 1998). "Immunoreactivity for prostate-specific antigen and prostatic acid phosphatase in adenocarcinoma of the prostate: relation to progression following radical prostatectomy.". Prostate 34 (1): 29-33. PMID 9428385.
- ↑ Azumi, N.; Traweek, ST.; Battifora, H. (Aug 1991). "Prostatic acid phosphatase in carcinoid tumors. Immunohistochemical and immunoblot studies.". Am J Surg Pathol 15 (8): 785-90. PMID 1712549.
- ↑ Koo J, Zhou X, Moschiano E, De Peralta-Venturina M, Mertens RB, Dhall D (December 2013). "The immunohistochemical expression of islet 1 and PAX8 by rectal neuroendocrine tumors should be taken into account in the differential diagnosis of metastatic neuroendocrine tumors of unknown primary origin". Endocr Pathol 24 (4): 184–90. doi:10.1007/s12022-013-9264-9. PMID 24037217.