Androgen receptor
Androgen receptor, abbreviated AR, is receptor activated by androgens (testosterone, dihydrotestosterone).
| Androgen receptor | |
|---|---|
| Immunostain in short | |
| Normal staining pattern | nuclear |
| Positive | salivary duct carcinoma, Brenner tumour, apocrine carcinoma of the breast, prostate carcinoma (most cases) |
Tumours with AR
- Salivary duct carcinoma +ve ~90% of cases.[1]
- Ovarian Brenner tumour.[2]
- Apocrine carcinoma of the breast - usu. smaller tumours.[3]
- Prostate carcinoma with amphicrine features.[4]
Antibodies
Various clone exist and they target different regions/variants; an incomplete list includes:
- AR N-terminus.
- AR C-terminus.
- AR v7.
See also
References
- ↑ Fan, CY.; Wang, J.; Barnes, EL. (Apr 2000). "Expression of androgen receptor and prostatic specific markers in salivary duct carcinoma: an immunohistochemical analysis of 13 cases and review of the literature.". Am J Surg Pathol 24 (4): 579-86. PMID 10757407.
- ↑ Kuhn, E.; Ayhan, A.; Shih, IeM.; Seidman, JD.; Kurman, RJ. (Dec 2013). "Ovarian Brenner tumour: a morphologic and immunohistochemical analysis suggesting an origin from fallopian tube epithelium.". Eur J Cancer 49 (18): 3839-49. doi:10.1016/j.ejca.2013.08.011. PMID 24012099.
- ↑ Honma, N.; Takubo, K.; Akiyama, F.; Sawabe, M.; Arai, T.; Younes, M.; Kasumi, F.; Sakamoto, G. (Aug 2005). "Expression of GCDFP-15 and AR decreases in larger or node-positive apocrine carcinomas of the breast.". Histopathology 47 (2): 195-201. doi:10.1111/j.1365-2559.2005.02181.x. PMID 16045781.
- ↑ Prendeville, S.; Al-Bozom, I.; Compérat, E.; Sweet, J.; Evans, AJ.; Ben-Gashir, M.; Mete, O.; van der Kwast, TH. et al. (Dec 2017). "Prostate carcinoma with amphicrine features: further refining the spectrum of neuroendocrine differentiation in tumours of primary prostatic origin?". Histopathology 71 (6): 926-933. doi:10.1111/his.13330. PMID 28756619.