P53

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p53 is a tumour suppressor commonly implicated in cancer and common immunostain.

P53
Immunostain in short

p53 staining in an anaplastic astrocytoma.
Use cancer versus benign, prognostication
Positive nuclear staining

Interpretation

  • p53 may be one of the most misinterpreted stains.
    • TP53 mutations are associated with >60% staining and no staining (0% of cell labelled).[1]

See also

References

  1. Yemelyanova, A.; Vang, R.; Kshirsagar, M.; Lu, D.; Marks, MA.; Shih, IeM.; Kurman, RJ. (Sep 2011). "Immunohistochemical staining patterns of p53 can serve as a surrogate marker for TP53 mutations in ovarian carcinoma: an immunohistochemical and nucleotide sequencing analysis.". Mod Pathol 24 (9): 1248-53. doi:10.1038/modpathol.2011.85. PMID 21552211.