Atypical lobular hyperplasia

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Atypical lobular hyperplasia, abbreviated ALH, a pre-malignant change in the breast characterized by cellular proliferation and cellular dyscohesion.

Atypical lobular hyperplasia
Diagnosis in short

Atypical lobular hyperplasia. H&E stain. (WC/Nephron)
LM DDx lobular carcinoma in situ, lobular carcinoma
IHC E-cadherin -ve
Site breast

Prognosis benign

It can be seen as the precursor to lobular carcinoma in situ, the precursor of lobular carcinoma.

General

  • May occur with ductal involvement by cells of atypical lobular hyperplasia (abbreviated DIALH).[1]
    • ALH with DIALH has a risk of developing breast cancer that is similar to LCIS.

Microscopic

Features:

DDx:

Images

IHC

  • E-cadherin -ve or incomplete membrane staining.

See also

References

  1. Page, DL.; Dupont, WD.; Rogers, LW. (Feb 1988). "Ductal involvement by cells of atypical lobular hyperplasia in the breast: a long-term follow-up study of cancer risk.". Hum Pathol 19 (2): 201-7. PMID 3343034.