Paneth cell

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The Paneth cell is characteristic of the small intestine. It is also normal in the cecum, ascending colon and transverse colon.

Paneth cell metaplasia and lamina propria eosinophils. H&E stain.

Paneth cell metaplasia, abbreviated PCM, redirects to this article.

General

  • Paneth cells should not be in the left colon.[1]
    • If you see 'em there it is Paneth cell metaplasia.

Paneth cell metaplasia

If PCM is present:

Microscopic

Features:

  • Supranuclear eosinophilic granules.

DDx:

  • Enterochromaffin cells (AKA Kulchitsky cells).
    • Subnuclear eosinophilic granules.
  • Intraepithelial eosinophils.
    • Eosinophils have smaller (~1/2) more intensely red granules.

Images

  • PCM - intermed. mag. (WC)

  • PCM - high mag. (WC)

  • PCM - very high mag. (WC)

  • PCM - extremely high mag. (WC)

IHC

  • Lysozyme +ve.[2]

See also

References

  1. ↑ Tanaka M, Saito H, Kusumi T, et al (December 2001). "Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease". J. Gastroenterol. Hepatol. 16 (12): 1353–9. PMID 11851832. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353.
  2. ↑ Rubio CA, Nesi G (2003). "A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections". In Vivo 17 (1): 67–71. PMID 12655793.
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