Anaplastic astrocytoma
Anaplastic astrocytoma (AKA: high-grade astrocytoma) is a infiltrating neoplasm of the diffuse astrocytic and oligodendroglial tumor group occurring in the CNS white matter.
- Most common grade III WHO glioma in adults (peaks between 40-50 years).
- Approx 5% of all gliomas.[1]
- Usually shows progression to glioblastoma sooner or later.
WHO 2016 categorization combines morphology and genetics into following groups:[2]
- Anaplastic astrocytoma, IDH-mutant (ICD-O: 9401/3).
- Anaplastic astrocytoma, IDH-wildtype (ICD-O: 9400/3).
- Anaplastic astrocytoma,NOS (ICD-O: 9400/3) - genetic data missing.
Radiology/Clinic
- Mass effect.
- Seizures.
- Neurologic decifit.
- The majority are contrast-enhanching, T2 bright.
Macroscopy
- No clear demarcation from white matter.
- Invaded structures may appear enlarged.
- Softer consistency and opacity.
- No necrosis.
- ↑ Ohgaki, H.; Kleihues, P. (Jun 2005). "Population-based studies on incidence, survival rates, and genetic alterations in astrocytic and oligodendroglial gliomas.". J Neuropathol Exp Neurol 64 (6): 479-89. PMID 15977639.
- ↑ Louis, DN.; Perry, A.; Reifenberger, G.; von Deimling, A.; Figarella-Branger, D.; Cavenee, WK.; Ohgaki, H.; Wiestler, OD. et al. (Jun 2016). "The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary.". Acta Neuropathol 131 (6): 803-20. doi:10.1007/s00401-016-1545-1. PMID 27157931.