Spindle cell lesions are seen frequent enough that one ought to have a solid approach to 'em.
General DDx
Spindle cells should make think:
Malignant fibrous histiocytoma
Work-up (MSH):
- CD34 - GIST, angiosarcoma.
- S100 - neural.
- Desmin - smooth muscle.
- MIB-1 - proliferation.
- CD99 - small blue cell tumours.
- Bcl-2.
- PGP 9.5.
- SMMS - smooth muscle.
- Caldesmon - muscle.
- PDGFR - GIST.
- DOG-1 - GIST (membranous, cytoplasmic),[1] normal pancreas (islets),[1] associated with BRCA1.
See alsoReferences
- ↑ 1.0 1.1 Ardeleanu C, Arsene D, Hinescu M, et al. (October 2009). "Pancreatic expression of DOG1: a novel gastrointestinal stromal tumor (GIST) biomarker". Appl. Immunohistochem. Mol. Morphol. 17 (5): 413–8. doi:10.1097/PAI.0b013e31819e4dc5. PMID 19417627.