Adenocarcinoma of the urinary bladder

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Adenocarcinoma of the urinary bladder, also primary adenocarcinoma of the urinary bladder and bladder adenocarcinoma, is a very uncommon malignant urinary bladder tumour.

Adenocarcinoma of the urinary bladder
Diagnosis in short

Adenocarcinoma of the urinary bladder. H&E stain.

Synonyms primary adenocarcinoma of the urinary bladder

LM nuclear pleomorphism (may be mild), usually glandular differentiation (most common), no urothelial differentiation - essential
LM DDx urachal carcinoma, invasive urothelial carcinoma with glandular differentiation, metastatic adenocarcinoma (esp. colorectal adenocarcinoma)
IHC CK7 +ve, CK20 +ve, CDX2 +ve (strong, diffuse), beta-catenin +ve (membranous, not nuclear)
Grossing notes radical cystectomy grossing, cystoprostatectomy grossing
Site urinary bladder

Prevalence rare
Treatment cystectomy

General

Clinical:

Microscopic

Features:

  • Nuclear pleomorphism - may be mild.
  • Usually glandular differentiation (most common).
  • Without urothelial differentiation - essential.[3]

Subtypes:[2]

  • Glandular.
  • Papillary.
  • Colloidal (mucinous).
  • Signet ring cell carcinoma.
  • Clear cell carcinoma (also mesonephroid carcinoma).

DDx:

Images

Case 1

IHC

Features - variable:[4]

Images

Case 1

See also

References

  1. 1.0 1.1 Ranadive, NU.; Trivedi, VD.; Gadgil, NM. (Oct 1999). "Primary adenocarcinoma of the urinary bladder: a study of 6 cases from the pathologist's point of view.". Arch Esp Urol 52 (8): 906-11. PMID 11762445.
  2. 2.0 2.1 Abbas, M.; Kramer, MW.; Wolters, M.; Herrman, TR.; Becker, JU.; Kreipe, HH. (Feb 2013). "Adenocarcinoma of the urinary bladder, mesonephroid type: a rare case.". Rare Tumors 5 (1): e3. doi:10.4081/rt.2013.e3. PMID 23772302.
  3. Zhong, M.; Gersbach, E.; Rohan, SM.; Yang, XJ. (Mar 2013). "Primary adenocarcinoma of the urinary bladder: differential diagnosis and clinical relevance.". Arch Pathol Lab Med 137 (3): 371-81. doi:10.5858/arpa.2012-0076-RA. PMID 23451748.
  4. Roy, S.; Parwani, AV. (Dec 2011). "Adenocarcinoma of the urinary bladder.". Arch Pathol Lab Med 135 (12): 1601-5. doi:10.5858/arpa.2009-0713-RS. PMID 22129192.