Plasmacytoid urothelial carcinoma

Plasmacytoid urothelial carcinoma is a rare aggressive variant of urothelial carcinoma.

General

Features:^[1]

Aggresive.
Uncommon.
Often associated with positive margins (relative to other UCC variants); spreads along fascial planes.^[2]

Features:

Plasmacytoid morphology:
- Abundant gray cytoplasm.
- Eccentric nucleus - usually round, occasionally crescentic.
+/-Mucous (common).

Features:^[3]

AE1/AE3 +ve (16 +ve/16 cases).
EMA +ve (16 +ve/16 cases).
CK7 +ve (16 +ve/16 cases).
CK20 +ve (16 +ve/16 cases).
CD138 (15 +ve/16 cases).
p63 (11 +ve/16 cases).

↑ Qin, M.; Wang, G.; Sun, Y.; He, Q.. "Plasmacytoid urothelial carcinoma of the bladder.". Indian J Pathol Microbiol 57 (2): 320-2. doi:10.4103/0377-4929.134730. PMID 24943778.
↑ Kaimakliotis, HZ.; Monn, MF.; Cheng, L.; Masterson, TA.; Cary, KC.; Pedrosa, JA.; Foster, RS.; Koch, MO. et al. (May 2014). "Plasmacytoid bladder cancer: variant histology with aggressive behavior and a new mode of invasion along fascial planes.". Urology 83 (5): 1112-6. doi:10.1016/j.urology.2013.12.035. PMID 24582117.
↑ Zhang, W.; Jiang, YX.; Liu, Y.; Yu, WJ.; Zhao, H.; Li, YJ. (Jul 2013). "[Plasmacytoid urothelial carcinoma of the urinary bladder: a clinicopathologic study of 16 cases].". Zhonghua Bing Li Xue Za Zhi 42 (7): 433-7. PMID 24246859.