Bizarre parosteal osteochondromatous proliferation

Bizarre parosteal osteochondromatous proliferation
	Diagnosis in short
Synonyms	Nora lesion
Site	Hands, feet

General

A distinctive osteochondromatous proliferation of hands and feet.

Population

Young adults
20s-30s

Location

Hands and feet

Radiology

Marginated wide based bony growth projecting into the soft tissues^[1]

Gross

Nodule covered with glistening cartilage

Microscopic

Disorganized cellular cartilage with a blue tint and patchy ossification matures into disorganized bone. A proliferation of fibroblasts surrounds the lesion and occupies intertrabecular spaces.

Images

Image:

Notice the disorganized blue tinted cartilage with partial ossification merging into mature bone.

Image:

A loose proliferation of fibroblasts fills the spaces between the bony trabeculae.

BPOP[1]
BPOP[2]
BPOP[3]
BPOP[4]

DDX

Periosteal chondrosarcoma
Periosteal chondroma
Low grade parosteal osteosarcoma
Osteochondroma

Diangostic categories

Cartilaginous neoplasms
Osteocartilaginous neoplasms

Molecular

t(1:17)(q32;q21)^[2]

Sign out

BIZARRE PAROSTEAL OSTEOCHONDROMATOUS PROLIFERATION (NORA LESION).
APPROPRIATE MARGIN STATEMENT.

Prognosis

Benign
Locally aggressive

References

↑ http://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation
↑ Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.

[1] ttp://radiopaedia.org/articles/bizarre-parosteal-osteochondromatous-proliferation

[2] Kuruvilla, S.; Marco, R.; Raymond, AK.; Al-Ibraheemi, A.; Tatevian, N. (2011). "BizarreParosteal Osteochondromatous Proliferation (Nora's lesion) with translocation t(1;17)(q32;q21): a case report and role of cytogenetic studies on diagnosis.". Ann Clin Lab Sci 41 (3): 285-7. PMID 22075515.

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