Granulocytic sarcoma
Granulocytic sarcoma is an uncommon malignant soft tissue lesion that really represents a hematologic malignancy; it is a soft tissue manifestation of acute myeloid leukemia. It is not a sarcoma.
| Granulocytic sarcoma | |
|---|---|
| Diagnosis in short | |
 Chloroma. H&E stain. | |
|
| |
| Synonyms | extramedullary leukemia, myeloid sarcoma and chloroma, myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, myelosarcoma |
|
| |
| LM | atypical small blue cells ~2x resting lymphocyte, infiltrative |
| LM DDx | small round cell tumours |
| Site | soft tissue lesion |
|
| |
| Prevalence | rare |
| Clin. DDx | other soft tissue lesions |
| Treatment | see acute myeloid leukemia |
Numerous other terms refer to this including extramedullary leukemia,[1] myeloid sarcoma and chloroma.
Less common terms include:[2] myeloblastoma, chloromyeloma, chloromyelosarcoma, granulocytic leukosarcoma, and myelosarcoma.
General
- Soft tissue manifestation of acute myeloid leukemia.[2]
Microscopic
Features:
- Cluster of atypical small blue cells in soft tissue with scant cytoplasm.
DDx:
- Small cell carcinoma
- Large cell lymphomas (DLBCL, ALCL).
- Other small round cell tumours.
Images
Chloroma - intermed. mag. (WC)
Chloroma - high mag. (WC)
Chloroma - very high mag. (WC)
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- It is prudent to mention acute myeloid leukemia somewhere in the report to ensure the appropriate referral is made.
See also
References
- ↑ Bakst, RL.; Tallman, MS.; Douer, D.; Yahalom, J. (Oct 2011). "How I treat extramedullary acute myeloid leukemia.". Blood 118 (14): 3785-93. doi:10.1182/blood-2011-04-347229. PMID 21795742.
- ↑ 2.0 2.1 Eom, KS.; Kim, TY. (Mar 2011). "Intraparenchymal myeloid sarcoma and subsequent spinal myeloid sarcoma for acute myeloblastic leukemia.". J Korean Neurosurg Soc 49 (3): 171-4. doi:10.3340/jkns.2011.49.3.171. PMC 3085814. PMID 21556238. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3085814/.