Basal crypt dysplasia

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Basal crypt dysplasia, abbreviated BCD, is a dysplastic change reported in the esophagus that involves the crypt bases but not the surface.[1]

It may be referred to as crypt dysplasia-like atypia[2] and crypt dysplasia (abbreviated CD).

Conventional dysplasia is said to always involve the surface epithelium.

BCD violates the saying normal is dark deep and light luminal.

General

  • Molecular changes in the crypt base can be identified in the surface cells.[1]
  • Strong association with conventional dysplasia/adenocarcinoma.
    • In one series, 87% of individual with BCD had dysplasia or adenocarcinoma in other tissue samples.[2]

Microscopic

Features:

  • Definite "dysplastic changes" in the crypt base:
    • Hyperchromasia - important.
    • Nuclear enlargement.
    • Nuclear crowding (pseudostratification).
  • Non-dysplastic (normal) surface epithelium.[1]

See also

References

  1. ↑ 1.0 1.1 1.2 Khan, S.; McDonald, SA.; Wright, NA.; Graham, TA.; Odze, RD.; Rodriguez-Justo, M.; Zeki, S. (Sep 2013). "Crypt dysplasia in Barrett's oesophagus shows clonal identity between crypt and surface cells.". J Pathol 231 (1): 98-104. doi:10.1002/path.4211. PMID 23695891.
  2. ↑ 2.0 2.1 Lomo, LC.; Blount, PL.; Sanchez, CA.; Li, X.; Galipeau, PC.; Cowan, DS.; Ayub, K.; Rabinovitch, PS. et al. (Apr 2006). "Crypt dysplasia with surface maturation: a clinical, pathologic, and molecular study of a Barrett's esophagus cohort.". Am J Surg Pathol 30 (4): 423-35. PMID 16625087.
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