Coffee bean nucleus

Coffee bean nucleus is a cell nucleus that looks like a coffee bean. Coffee bean nuclei have a limited differential diagnosis.

Coffee bean nuclei in a Brenner tumour. H&E stain.

Microscopic

• Coffee bean nuclei are ellipsoid and have a central groove.

Image:

• Coffee bean nuclei in a Brenner tumour (WC).

Classic differential diagnosis

• Granulosa cell tumour.
• Brenner tumour.

Others considerations

• Invasive ductal carcinoma of the pancreas.
• Langerhans cell histiocytosis.
• Papillary thyroid carcinoma. (???)

See also

• Basics.
• Long power list.