Bile duct adenoma

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Bile duct adenoma is a benign liver lesion characterized composed of bile duct epithelium.

It is also known as a benign bile duct proliferation.[1]

General

  • Benign.
  • Important as it can be misdiagnosed as cancer.

Microscopic

Features:

  • Disordered bile ducts within in a fibrotic stroma.
    • No (yellow) bile within, as these lesions do not have a connection to the biliary tree.
    • +/-Lymphocytic cuff.

Negatives:

  • No mitotic activity.
  • No necrosis.

DDx:

Images

IHC

  • CK7 +ve.
  • HepPar-1 -ve.
  • HMGA1 -ve/+ve.
  • HMGA2 -ve/+ve.

Note:

  • HMGA1 & HMGA2 together may be useful for differentiating from adenocarcioma.[2]

See also

References

  1. Johannesen, EJ.; Wu, Z.; Holly, JS. (2014). "Bile duct adenoma with oncocytic features.". Case Rep Pathol 2014: 282010. doi:10.1155/2014/282010. PMID 24592348.
  2. Zakharov, V.; Ren, B.; Ryan, C.; Cao, W. (Apr 2013). "Diagnostic value of HMGAs, p53 and β-catenin in discriminating adenocarcinoma from adenoma or reactive atypia in ampulla and common bile duct biopsies.". Histopathology 62 (5): 778-87. doi:10.1111/his.12084. PMID 23530587.