Vocal cord nodule

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Vocal cord nodule, also vocal cord polyp and singer's nodule, is a benign pathology of the head and neck.

Vocal cord nodule
Diagnosis in short

Laryngeal nodule

Synonyms singer's nodule
LM DDx amyloidosis, granular cell tumour, spindle cell squamous cell carcinoma, myxoma, ductal-type cyst
Site vocal cord - see head and neck pathology

Prevalence common
Prognosis bening

General

  • Benign.
  • AKA singer's nodule.
  • Etiology: overuse, mechanical trauma (?).

Clinical:

Microscopic

Features:[2]

  • Early:
    1. Edema.
    2. Fibroblasts proliferation.
  • Late:
    1. Subepithelial hyaline / stromal hyaline.
    2. Blood vessels - dilated.

Notes:

  • No inflammation.

DDx:[3]

Images

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VOCAL CORD LESION, EXCISION:
- STRATIFIED SQUAMOUS EPITHELIUM WITH PARAKERATOSIS AND STROMAL EDEMA, CONSISTENT
  WITH BENIGN VOCAL CORD NODULE OR POLYP.
- NEGATIVE FOR MALIGNANCY.
VOCAL CORD LESION, EXCISION:
- STRATIFIED SQUAMOUS EPITHELIUM WITH PARAKERATOSIS AND SUBEPITHELIAL 
  HYALINE MATERIAL, CONSISTENT WITH WITH VOCAL CORD NODULE OR POLYP.
- NEGATIVE FOR MALIGNANCY.

See also

References

  1. Müller, R. (Nov 1995). "[Hoarseness].". Ther Umsch 52 (11): 759-62. PMID 7502253.
  2. URL: http://www.pathconsultddx.com/pathCon/diagnosis?pii=S1559-8675%2806%2970310-2. Accessed on: 4 February 2011.
  3. Thompson, Lester D. R. (2006). Head and Neck Pathology: A Volume in Foundations in Diagnostic Pathology Series (1st ed.). Churchill Livingstone. pp. 9. ISBN 978-0443069604.
  4. Soylu, L.; Aydogan, B.; Tunali, N.; Ozsahinoglu, C. (Aug 1999). "Report of a rare case of vocal fold carcinoma that was obscured by a prominent vocal fold polyp.". Ear Nose Throat J 78 (8): 601-2. PMID 10485155.
  5. Abdou, AG.; Asaad, NY. (Oct 2012). "Rheumatoid nodule of the vocal cord.". Int J Surg Pathol 20 (5): 481-2. doi:10.1177/1066896912448426. PMID 22674917.