Littoral cell angioma

Littoral cell angioma, abbreviated LCA, is an uncommon benign vascular lesion of the spleen.

Littoral cell angioma
Diagnosis in short
LM DDx	hemangioendothelioma, angiosarcoma, hemangiopericytoma, splenic hamartoma
Site	spleen
Prevalence	rare
Prognosis	benign

Angioma, in general, is dealt with in vascular malformations.

General

Features:

• Rare.
• Benign.

Clinical:

• Pyrexia (fever), splenomegaly, weight loss, solitary hypodense lesion on imaging.

Note:

• Littoral cells = line vascular channels of the red pulp.
  • Littoral = related to shore.

Microscopic

Features:

• Anastoming, small vascular channels.
• Cystic spaces.
  • May have papillary projections.

DDx:

• Vascular lesions:
  • Hemangioendothelioma.
  • Angiosarcoma.
  • Hemangiopericytoma.
  • Splenic hamartoma.

Images

• 

  LCA - very low mag. (WC)

• 

  LCA - low mag. (WC)

• 

  LCA - intermed. mag. (WC)

• 

  LCA - high mag. (WC)

• 

  LCA - very high mag. (WC)

www:

• LCA - low mag. (webpathology.com).
• LCA - high mag. (webpathology.com).

IHC

Features:

• CD68 +ve.
• CD31 +ve

Others:

• CD34 -ve.
• Factor VIII +ve.

See also

• Spleen.