Paneth cell
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The Paneth cell is characteristic of the small intestine. It is also normal in the cecum, ascending colon and transverse colon.
Paneth cell metaplasia. H&E stain.
Paneth cell metaplasia, abbreviated PCM, redirects to this article.
General
- Paneth cells should not be in the left colon.[1]
- If you see 'em there it is Paneth cell metaplasia.
Paneth cell metaplasia
If PCM is present:
- Think of inflammatory bowel disease and other long-standing injurious processes.
Note:
- Some claim that (friendly right colonic) paneth cells and paneth cell metaplasia look quite different and can be distinguished.[2]
Microscopic
Features:
- Supranuclear eosinophilic granules.
DDx:
- Enterochromaffin cells (AKA Kulchitsky cells).
- Subnuclear eosinophilic granules.
- Intraepithelial eosinophils.
- Eosinophils have smaller (~1/2) more intensely red granules.
See also
References
- ↑ Tanaka M, Saito H, Kusumi T, et al (December 2001). "Spatial distribution and histogenesis of colorectal Paneth cell metaplasia in idiopathic inflammatory bowel disease". J. Gastroenterol. Hepatol. 16 (12): 1353–9. PMID 11851832. http://www3.interscience.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0815-9319&date=2001&volume=16&issue=12&spage=1353.
- ↑ Rubio CA, Nesi G (2003). "A simple method to demonstrate normal and metaplastic Paneth cells in tissue sections". In Vivo 17 (1): 67–71. PMID 12655793.