Uterine cervix with atrophic changes

Uterine cervix with atrophic changes is relatively common and is important to recognize as it can mimic HSIL.

Uterine cervix with atrophic changes
Diagnosis in short
Atrophic cervix. H&E stain.
LM	small squamous cells with grey/blue cytoplasm, no "dancing"/"sparkling" chromatin, no mitoses
LM DDx	HSIL
IHC	p16 -ve, Ki-67 rare basal cells
Site	uterine cervix - exocervix
Clinical history	old
Prevalence	common
Prognosis	benign
Other	normal - postmenopausal

It is also known as atrophy of the uterine cervix, cervical atrophy, atrophy of the cervix and cervix with atrophic changes.

General

• Common.
• Post-menupausal.
• Important to recognize and differentiate from HSIL.

Microscopic

Features:

• Cells smaller.
• Cytoplasm grey/blue.
• No "dancing"/"sparkling" chromatin.
• No mitoses.

DDx:

• HSIL.

Images

• 

  AC - intermed. mag.

• 

  AC - high mag.

• 

  AC - high mag.

• 

  AC - very high mag.

• 

  AC - intermed. mag.

• 

  AC - high mag.

• 

  AC - very high mag.

www:

• Atrophic cervix (nih.techriver.net).
• Atrophic cervix (flickriver.com/euthman).
• Atrophic changes in the vagina (eurocytology.eu).

IHC

• p16 -ve.
• Ki-67 rare basal cells.

Sign out

UTERINE CERVIX, BIOPSY:
- SQUAMOUS MUCOSA WITH ATROPHIC CHANGES.
- BENIGN ENDOCERVICAL EPITHELIUM.
- NEGATIVE FOR DYSPLASIA.

COMMENT:
A p16 immunostain is negative. A Ki-67 immunostain marks rare basal cells.

See also

• Uterine cervix.