Talk:Neuropathology tumours
Glioblastoma
Microscopic
Sections show an infiltrating tumour composed of randomly arranged cells of astroglial origin, as shown by their eosinophilic cytoplasm drawn into processes. There is marked nuclear pleomorphism, abundant mitotic activity, vigorous microvascular proliferation and extensive areas of necrosis with pseudopalisading of tumour.
Final diagnosis
BRAIN:
-GLIOBLASTOMA (WHO GRADE IV).
Meningioma
Microscopic
The microscopic section/sections shows a moderately cellular with lesion with prominent whorls, thick-walled blood vessels and focal calcifications.
There are less than 4 mitoses / HPF, where 1 HPF is approximately 0.2376 mm^2. There are no macronucleoli, no sheeting architecture, no hypercellularity, and no spontaneous necrosis. The cells of the lesion do not have a high nuclear-to-cytoplasmic ratio.
Final diagnosis
MENINGIOMA, GRADE 1.
Anaplastic astrocytoma
Microscopic
The microscopic section/sections shows white matter with tumour. The tumour cell nuclei are oblong and have a marked irregular profile and occasionally eosinophilic cytoplasm. Mitoses are rare/common. There is no necrosis and no microvascular proliferation. Immunohistochemistry shows GFAP staining of the perikaryon in cytologically malignant cells. Occasional/Many/All tumour cells stain for p53. The Ki-67 is positive in approximately X% of tumour cells.
Final diagnosis
ANAPLASTIC ASTROCYTOMA, WHO GRADE 3.
Oligodendroglioma
Microscopic
The microscopic section/sections shows regularly distributed cells with round nuclei that are surrounded by clear halos. No mitoses are present. Microvascular proliferation is not seen. The nuclear atypia is mild-to-moderate. There is no nuclear overlapping.
Final diagnosis
OLIGODENDROGLIOMA, WHO GRADE 2.
Hemangioblastoma
Microscopic
The sections show a partially cystic vascular tumour with histomorphological normal endothelial cells and vacuolated polygonal cells with hyperchromatic nuclei. There is no mitotic activity. The tumour has a poorly demarcated border. Cerebellum adjacent to the tumour demonstrates Purkinje cell loss and Bergmann gliosis.
Immunohistochemical staining shows that the tumour is positive focally and weakly for inhibin and is strongly positive for neuron-specific enolase (NSE).
Final diagnosis
BRAIN, CEREBELLUM, EXCISION:
- HEMANGIOBLASTOMA.