Endometrium with changes due to exogenous hormones
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Endometrium with hormonal changes is relatively common in endometrial samples.
Endometrial changes of oral contraception | |
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External resources | |
EHVSC | 10170 |
Endometrial changes of oral contraception, oral contraceptive effect and OCP endometrium redirect here.
The oral contraceptive pill is dealt with in the article oral contraceptive pill.
General
- Very common.
- Most pills a mix of progesterone and estrogen.
- The progesterone is what generates the characteristic appearance -- that is similar to pregnancy.
Microscopic
Features:[1]
- Inactive glands (round/ovoid glands, simple cuboidal epithelium, no mitoses).
- Stroma decidualized -- mnemonic NEW:
- Nucleus central.
- Eosinophilic cytoplasm.
- Well-defined cell borders.
DDx:
- Endometrial hyperplasia with secretory changes - proliferative activity.
- Secretory phase endometrium - glandular changes of the secretory phase (cytoplasmic vacuolization), secretions in the glands.
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ENDOMETRIUM, BIOPSY: - NON-PROLIFERATIVE ENDOMETRIAL GLANDS WITH STROMAL DECIDUALIZATION, CONSISTENT WITH EXOGENOUS HORMONES.
OCP effect and shedding endometrium
ENDOMETRIUM, ASPIRATION: - ENDOMETRIUM WITH NONPROLIFERATIVE ENDOMETRIAL GLANDS AND STROMAL DECIDUALIZATION, COMPATIBLE WITH EXOGENOUS HORMONES. - EVIDENCE OF ENDOMETRIAL SHEDDING (BALLS OF CONDENSED STROMA ASSOCIATED NEUTROPHILS, AND BLOOD). - NEGATIVE FOR HYPERPLASIA AND NEGATIVE FOR MALIGNANCY.
See also
References
- ↑ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease (7th ed.). St. Louis, Mo: Elsevier Saunders. pp. 1082. ISBN 0-7216-0187-1.