Nodular fasciitis
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Nodular fasciitis is an uncommon soft tissue lesion. It should not to be confused with necrotizing fasciitis.
| Nodular fasciitis | |
|---|---|
| Diagnosis in short | |
 Nodular fasciitis. H&E stain. | |
|
| |
| LM | usu. well-circumscribed, clusters of (non-pleomorphic) spindle cells, inflammation (lymphocytes), microcysts in cellular regions - uncommon, mitoses - common, extravasated RBCs. |
| IHC | CD34 -ve, desmin -ve, SMA -ve, S-100 -ve, AE1/AE3 -ve. |
| Molecular | t(15;15) ? |
| Site | soft tissue - fibroblastic/myofibroblastic tumours |
|
| |
| Clinical history | associated with trauma |
| Prevalence | uncommon |
| Prognosis | benign |
General
- Benign.
- All age groups.
- Associated with trauma.
Microscopic
- Usu. well-circumscribed.
- Clusters of (non-pleomorphic) spindle cells.
- Inflammation (lymphocytes).
- Microcysts in cellular regions - uncommon - discriminatory.
- Mitoses - common.
- Extravasated RBCs.
- Tissue culture-like/CNS-like morphology.
- Thick (keloid-like) collagen bundles - key feature.
- Extravasated RBCs.
- Inflammation.
- +/-Giant cells.
Notes:
- No significant nuclear atypia.
- No atypical mitoses.
- May be cellular.
DDx:[5]
- Myxoid DFSP.
- Cellular dermatofibroma.
- Desmoid-type fibromatosis.
Images
NF - case 1 - intermed. mag. (WC)
NF - case 1 - high mag. (WC)
NF - case 2 - intermed. mag. (WC)
NF - case 2 - high mag. (WC)
NF - low mag. (WC)
NF - high mag. (WC)
.JPG)
.JPG)
www:
IHC
Routine spindle cell panel:
- CD34 -ve.
- Desmin -ve.
- SMA -ve.
- S-100 -ve.
- AE1/AE3 -ve.
Others:
- H-caldesmon -ve.
- EMA -ve.
- Vimentin +ve.
Molecular
- Evolving - case reports.
- t(15;15)(q13;q25).[6]
See also
References
- ↑ Humphrey, Peter A; Dehner, Louis P; Pfeifer, John D (2008). The Washington Manual of Surgical Pathology (1st ed.). Lippincott Williams & Wilkins. pp. 606. ISBN 978-0781765275.
- ↑ de Feraudy S, Fletcher CD (September 2010). "Intradermal nodular fasciitis: a rare lesion analyzed in a series of 24 cases". Am. J. Surg. Pathol. 34 (9): 1377–81. doi:10.1097/PAS.0b013e3181ed7374. PMID 20716998.
- ↑ Dickson, B. 26 April 2011.
- ↑ URL: http://anvita.info/wiki/Nodular_Fasciitis. Accessed on: 11 November 2011.
- ↑ URL: http://www.mckeedermpath.com/SPOT%20DIAGNOSIS%20CASE%20268.html. Accessed on: 11 November 2011.
- ↑ Velagaleti GV, Tapper JK, Panova NE, Miettinen M, Gatalica Z (March 2003). "Cytogenetic findings in a case of nodular fasciitis of subclavicular region". Cancer Genet. Cytogenet. 141 (2): 160–3. PMID 12606136.