Talk:Urothelium

Dysplasia

URINARY BLADDER LESION, DOME, BIOPSY:
- UROTHELIAL DYSPLASIA, SEE COMMENT.
- BENIGN MUSCULARIS PROPRIA.

COMMENT:
The urothelium's nuclei have mild atypia, as would be seen in a low-grade papillary
urothelial carcinoma. 

Immunostaining is as follows:
p53 - weak to moderate staining of 10% of the urothelium, predominantly basal.
CK20 - focal staining of surface cells (umbrella cells), otherwise negative.
Ki-67 - 20-30% of urothelium, predominantly basal.