Chronic granulomatous disease

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Chronic granulomatous disease, abbreviated CGD, is a specific diagnosis; it should not be understood as a granulomatous disease that is of a long duration.

CGD is disorder of neutrophils[1] and typically leads to widespread granulomas.[2]

General

  • Five different genetic defects have been identified that cause the disease.
  • Individual with the condition have an increased susceptibility to infections.

Microscopic

Features:

DDx:

  • Crohn's disease - essentially indistinguishable histomorphologically in the GI tract.Marks, DJ.; Miyagi, K.; Rahman, FZ.; Novelli, M.; Bloom, SL.; Segal, AW. (Jan 2009). "Inflammatory bowel disease in CGD reproduces the clinicopathological features of Crohn's disease.". Am J Gastroenterol 104 (1): 117-24. doi:10.1038/ajg.2008.72. PMID 19098859.</ref>

References

  1. ↑ Cite error: Invalid <ref> tag; no text was provided for refs named pmid19098859
  2. ↑ Seger RA (November 2010). "Chronic granulomatous disease: recent advances in pathophysiology and treatment". Neth J Med 68 (11): 334–40. PMID 21116026.
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